Evidence map›Paper›PMID 41815064›Full record

ArticleACS chemical biology2026

Biosynthesis of Peptidic Thiooxazole Metallophores Installed by Multinuclear Nonheme Iron Enzymes.

Mayuresh G Gadgil, Shravan R Dommaraju, Xiaopeng Liu, Alexander J Battiste, Miriam H Bregman, Douglas A Mitchell

Abstract read
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Thiooxazole Formation on a NontypeablebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mayuresh G GadgilDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Shravan R DommarajuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-0565-1748
Xiaopeng LiuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Alexander J BattisteDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Miriam H BregmanDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Douglas A MitchellDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-9564-0953

Funding

A Scalable Platform to Discover Antimicrobials of Ribosomal OriginR01AI144967 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Douglas Alan Mitchell, WILFRED A. VAN DER DONK · 2019 to 2026
$6.0M
Discovery and Engineering of RiPP Natural ProductsR35GM158411 · NIGMS · VANDERBILT UNIVERSITY · PI Douglas Alan Mitchell · 2025 to 2026
$1.2M
A Thermo Q Exactive UHMR Instrument for Native Mass SpectrometryS10OD034244 · OD · VANDERBILT UNIVERSITY · PI SCHEY, KEVIN L · 2023 to 2023
$781k
NIAID NIH HHS R01 AI144967NIGMS NIH HHS R35 GM158411NIH HHS S10 OD034244
6 · The paper itself

Abstract

Significant effort has been directed toward the characterization of nonheme iron enzymes owing to their breadth of unique reactivity. Through genome mining, we identified a conserved biosynthetic gene cluster within Pseudomonadota encoding one such family, the multinuclear nonheme iron-dependent oxidative enzymes (MNIO, formerly DUF692). Using a representative gene cluster from

Indexed as

IronOxazolesPeptidesCopperHaemophilus influenzaeMultigene FamilyNeisseria gonorrhoeaeCopperIronOxazolesPeptides

Identifiers

PMID41815064
PMCPMC13097082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.