Evidence map›Paper›PMID 41814948›Full record

ArticleDevelopment (Cambridge, England)2026

Coordinating meiotic prophase I progression and early oocyte differentiation.

Kimberly M Abt, Myles A Bartholomew, Anna E K Nixon, Hanna E Richman, Megan A Gura, Kimberly A Seymour, Richard N Freiman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kimberly M AbtMCB Graduate Program, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.
Myles A BartholomewMCB Graduate Program, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.
Anna E K NixonMCB Graduate Program, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.
Hanna E RichmanDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.
Megan A GuraMCB Graduate Program, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.
Kimberly A SeymourDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.
Richard N FreimanMCB Graduate Program, Brown University, 70 Ship Street, Box G-E4, Providence, RI 02903, USA.ORCID 0000-0002-7269-3630

Funding

Dynamic Regulation of the Ovarian ReserveR01HD091848 · NICHD · BROWN UNIVERSITY · PI FREIMAN, RICHARD NEIL · 2018 to 2021
$1.7M
Regulating Establishment of the Mammalian Ovarian ReserveR01HD113567 · NICHD · BROWN UNIVERSITY · PI Richard Neil Freiman · 2024 to 2026
$1.4M
Fertility and TAF4b: Transcriptional Regulation of Murine Ovarian Reserve EstablishmentF31HD105340 · NICHD · BROWN UNIVERSITY · PI ABT, KIMBERLY M · 2021 to 2023
$140k
Unscrambling Eggs: TAF4B and Transcriptional Regulation of Meiosis I in Mouse OocytesF31HD097933 · NICHD · BROWN UNIVERSITY · PI GURA, MEGAN A · 2018 to 2021
$136k
Brown UniversityNational Institute of Child Health and Human Development 1F31HD097933National Institute of Child Health and Human Development 1F31HD105340National Institute of Child Health and Human Development 1R01HD091848National Institute of Child Health and Human Development 1R01HD113567National Institute of Child Health and Human Development HD091848National Institute of Child Health and Human Development HD097933National Institute of Child Health and Human Development HD105340National Institute of Child Health and Human Development HD113567NICHD NIH HHS F31 HD097933NICHD NIH HHS F31 HD105340NICHD NIH HHS R01 HD091848NICHD NIH HHS R01 HD113567United States-Israel Binational Science Foundation 2019285
6 · The paper itself

Abstract

Female reproductive senescence results from the regulated depletion of a finite pool of oocytes called the ovarian reserve. This pool of oocytes is initially established during fetal development, but the oocytes that it consists of must remain quiescent for decades until they are activated during maturation in adulthood. In order for developmentally competent oocytes to populate the ovarian reserve, they must successfully initiate both meiosis and oogenesis. As the factors that regulate the timing and fidelity of these early events remain elusive, we assessed the precise function and timing of the transcriptional regulator TAF4b during meiotic prophase I progression in mouse fetal oocytes. Compared to matched controls, E14.5 Taf4b-deficient oocytes enter meiosis I in a timely manner; however, their subsequent progression through the pachytene-to-diplotene transition of meiotic prophase I is compromised. Moreover, this disruption of meiotic progression is associated with the reduced ability of Taf4b-deficient oocytes to repair double-strand DNA breaks. Transcriptional profiling of Taf4b-deficient oocytes reveals that between E16.5 and E18.5 these oocytes fail to properly coordinate the reduction of meiotic gene expression and the activation of oocyte differentiation genes.

Indexed as

Cell DifferentiationMeiotic Prophase IOocytesOogenesisAnimalsDNA Breaks, Double-StrandedFemaleGene Expression Regulation, DevelopmentalMiceTATA-Binding Protein Associated FactorsTranscription Factor TFIIDTaf4b protein, mouseTATA-Binding Protein Associated FactorsTranscription Factor TFIIDFemale infertilityFetal oocyte attritionMeiosisOogenesisOvarian reserveTranscription

Identifiers

PMID41814948
PMCPMC13120671

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.