Evidence map›Paper›PMID 41814937›Full record

ArticleCell proliferation2026

Three-Dimensional Architecture of Ectopic Epithelium and Vasculature in Ovarian Endometriosis Revealed by Tissue-Clearing Imaging.

Fanyuan Sun, Shuzhen Wang, Jinyan Zhao, Jinhua Leng, Xili Zhu, Chongdong Liu, Jing Chen, Jinming Guo, Bangjing Jiang, Haihe Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fanyuan SunCapital University of Physical Education and Sports, Beijing, China.
Shuzhen WangDepartment of Obstetrics and Gynecology, Beijing ChaoYang Hospital, Capital University of Medical Science, Beijing, China.
Jinyan ZhaoCapital University of Physical Education and Sports, Beijing, China.
Jinhua LengDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.ORCID https://orcid.org/0000-0001-5604-4019
Xili ZhuInstitute of Zoology, Chinese Academy of Sciences, Beijing, China.
Chongdong LiuDepartment of Obstetrics and Gynecology, Beijing ChaoYang Hospital, Capital University of Medical Science, Beijing, China.
Jing ChenCapital University of Physical Education and Sports, Beijing, China.
Jinming GuoCapital University of Physical Education and Sports, Beijing, China.
Bangjing JiangCapital University of Physical Education and Sports, Beijing, China.
Haihe ZhouCapital University of Physical Education and Sports, Beijing, China.
Zhuoying LiCapital University of Physical Education and Sports, Beijing, China.
Hua LiDepartment of Obstetrics and Gynecology, Beijing ChaoYang Hospital, Capital University of Medical Science, Beijing, China.
Menghui LiDepartment of Obstetrics and Gynecology, Beijing ChaoYang Hospital, Capital University of Medical Science, Beijing, China.ORCID https://orcid.org/0000-0003-1300-5647
Yongcun QuCapital University of Physical Education and Sports, Beijing, China.

Funding

Emerging Interdisciplinary Platform for Medicine and Engineering in SportsThe National Key R&D Program of China 2022YFC2704000the National Natural Science Foundation of China 82501949Young Elite Scientists Sponsorship Program
6 · The paper itself

Abstract

Ovarian endometriosis (OEM) is characterised by ectopic endometrial tissue growth within the ovary. In these ectopic lesions, the ectopic epithelium plays a crucial role in OEM progression and has been associated with malignant transformation in a subset of cases. However, conventional histology limits understanding of ectopic epithelial distribution, structure, and its perivascular microenvironment, thus impeding pathogenesis studies. To address this, we employed a modified tissue-clearing method and  three-dimensional (3D) imaging to systematically characterise OEM, revealing key, previously unreported spatial characteristics. We found significantly higher densities of ectopic epithelium and vasculature in the outer cystic wall versus the inner. Furthermore, our method improved the detection rate of ectopic epithelium and revealed its morphological polymorphism at both tissue and cellular levels. Besides, we demonstrated that vessels preferentially cluster around ectopic epithelium, with their distribution pattern strongly linked to the location of ectopic epithelium. Strikingly, we observed endometrial-like structures in lesional vasculature in 3 of 49 cases, representing a novel morphological observation that warrants further investigation. This study significantly advances our understanding of OEM histopathology, offering insights for clinical diagnosis and treatment.

Indexed as

ChoristomaEndometriosisImaging, Three-DimensionalOvaryAdultEpitheliumFemaleHumans

Identifiers

PMID41814937
PMCPMC13325998

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