ArticleSe pu = Chinese journal of chromatography2026
[Analysis of stimulating factors for serum copeptin based on liquid chromatography-tandem mass spectrometry].
Article in Se pu = Chinese journal of chromatography, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Copeptin， as a stable surrogate biomarker for arginine vasopressin （AVP）， plays an important role in the differential diagnosis of polyuria-polydipsia syndromes. Current guidelines recommend dynamic monitoring of copeptin levels during stimulation tests to assist in differentiating AVP deficiency （AVP-D） from primary polydipsia. Although these methods are well-established， they have certain limitations. Therefore， safer and more feasible stimulants with reliable effects are of clinical interest. Additionally， the currently available copeptin assay， which is based on time-resolved immunofluorescence assay， can be subject to interference from autoantibodies or hemolysis. This study aims to evaluate the effects of four common stimulants used in growth hormone function tests， namely levodopa， insulin， glucagon， and octreotide， on copeptin levels using a reliable liquid chromatography-tandem mass spectrometry （LC-MS/MS） method developed in our laboratory. A total of 62 subjects undergoing growth hormone function tests were retrospectively enrolled and stratified by stimulation type： levodopa （
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