ArticleSe pu = Chinese journal of chromatography2026
[Lipid metabolomics-based biomarker analysis of neonatal sepsis in serum and cerebrospinal fluid].
Article in Se pu = Chinese journal of chromatography, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neonatal sepsis remains a leading cause of morbidity and mortality among newborns worldwide. Despite advances in neonatal care， early diagnosis of sepsis remains challenging due to the lack of sensitive and specific biomarkers. While serum-based indicators have been widely studied， lipid metabolism in cerebrospinal fluid （CSF） remains relatively underexplored， limiting our understanding of central nervous system involvement （CNS） in the early stages of neonatal sepsis. This study aimed to systematically investigate lipid metabolic alterations in both serum and CSF samples from neonates with confirmed sepsis and to identify potential lipid biomarkers for early diagnosis. Seventeen neonates with blood culture-positive sepsis and seventeen controls with negative blood culture results were enrolled from the Neonatal Intensive Care Unit of Guangdong Women and Children Hospital （Women and Children's Hospital， Southern University of Science and Technology） between February 2020 and August 2023. Paired serum and CSF samples were collected and analyzed using targeted lipidomics based on liquid chromatography-tandem mass spectrometry （LC-MS/MS）. Univariate analyses， including Student's
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