ArticleSe pu = Chinese journal of chromatography2026
[Development of a liquid chromatography-tandem mass spectrometry method for steroid hormone detection during pregnancy and consistency analysis with chemiluminescence immunoassay].
Article in Se pu = Chinese journal of chromatography, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Steroid hormones play a critical role in maintaining pregnancy and supporting fetal development. Accurate quantification of these hormones is essential for evaluating the endocrine status during pregnancy. While chemiluminescence immunoassay （CLIA） is widely used in clinical practice in China， it has inherent methodological limitations. In contrast， liquid chromatography-tandem mass spectrometry （LC-MS/MS） has been internationally recognized for its superior analytical performance but remains underutilized in Chinese obstetric practice. Moreover， systematic evaluations comparing these two methods in pregnant women are still lacking. This study aimed to develop and validate an isotope-dilution LC-MS/MS method for the simultaneous quantification of four key steroid hormones， including cortisol， dehydroepiandrosterone sulfate （DHEAS）， testosterone， and 17-hydroxyprogesterone （17-OHP）. In addition， a consistency analysis was conducted between LC-MS/MS and CLIA among pregnant women. Method validation followed international bioanalytical guidelines， evaluating linearity， limits of quantification （LOQs）， recovery， and precision. Serum samples from 94 pregnant women were collected at Guangdong Women and Children Hospital between January 2022 and December 2023， and were analyzed using both LC-MS/MS and CLIA. Method comparison was performed using paired
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