ReviewJournal of neurochemistry2026
Engram Synapses and Synapse Dynamics in Memory Processing.
Review in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
Abstract
Synaptic plasticity is believed to underlie a range of cognitive functions, including learning and memory. Numerous studies have shown that memory formation not only modifies the strength of existing synapses but also alters the dynamics of synaptic turnover. The dynamics of the synaptic landscape reflect brain-wide genetic changes and the activation of molecular mechanisms that mediate pre- and postsynaptic structural plasticity. The activity-dependent nature of these mechanisms leads to an intriguing possibility that synapses between engram neurons across multiple brain regions, or "engram synapses," may act as a hub for such synaptic changes. This review aimed to highlight the close relationship between the dynamics of synapse turnover and memory storage and summarize the underlying molecular mechanisms involved. The analysis highlights the need for more systematic investigation into how engram-specific synapses form and are eliminated across different brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.