ArticleNeurological research and practice2026
Wearable sensor measurements in relation to clinical characteristics and mortality in patients with Parkinson's disease.
Article in Neurological research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03130595 (West Sweden Parkinson Objective Measurement Registry Study - an Observational Cohort Study of the Prevalence and Development of Motor Symptoms Assessed With Automated Accelerometry in People With Parkinson's Disease in West Sweden), which is not on this map. Cited by 1 paper.
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West Sweden Parkinson Objective Measurement Registry Study - an Observational Cohort Study of the Prevalence and Development of Motor Symptoms Assessed With Automated Accelerometry in People With Parkinson's Disease in West Sweden
Who cites it
1 citing paper in PubMed.
- Rethinking EDSS-based ambulation assessment in multiple sclerosis using continuous variable monitoring.Neurological research and practice · 2026Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson’s disease (PD) is highly variable between patients, and regular assessments are needed to adjust symptomatic treatment. Wearable sensor measurements can complement clinical examinations and patient-reported outcome measures in the management of PD, but their clinical usefulness is yet to be established. Previous studies have described wearable sensor measurements from selected patients, often with advanced disease, but not PD patients in general. We sought to objectively describe daily-life movement characteristics of population-representative patients with PD using the wrist-worn Personal KinetiGraph (PKG), and to relate these sensor measurements to clinical data and proposed PKG-based treatment targets.
methodsIndividuals in a population-based random sample of patients with PD were evaluated with clinical assessments, patient-reported outcome measures and six-day PKG recordings. PKG outcomes included bradykinesia score (BKS) and dyskinesia score (DKS), reflecting symptom severity. Mortality within eight years was recorded.
resultsThe study included 286 patients with a median age of 73 years and a median time since diagnosis of five years. Clinical and patient-reported variables expected to increase with disease or symptom severity were positively correlated with bradykinesia score (BKS) and negatively correlated with dyskinesia score (DKS). Patients with BKS > 25 had lower levodopa-equivalent daily dose, higher self-reported symptom burden and lower health-related quality of life compared to patients with BKS ≤ 25. Age- and sex-adjusted mortality rates were 1.8 times higher in patients with BKS > 25.
conclusionsSensor-based motor assessments with PKG reflect clinical outcome measures in population-representative PD patients. A high degree of sensor-assessed bradykinesia (BKS > 25) at baseline was associated with higher mortality, shorter disease duration and less intensive treatment. The results suggest that high BKS is a risk factor for mortality, possibly as a marker of undertreatment.
trial registrationClinicalTrials.gov identifier NCT03130595, registration date 22 April 2017.
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