Evidence map›Paper›PMID 41814441›Full record

ArticleEnvironmental microbiome2026

Exploring the biotechnological potential of terrestrial hot spring microbiomes for CO

Christopher E Stead, Leanne Walker, Carla Greco, Toni Galloway, Claire R Cousins, Franziska Nagel, Rainer Breitling, Eriko Takano, Snaedís Huld Björnsdóttir, Sophie L Nixon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher E SteadManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Leanne WalkerManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Carla GrecoManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Toni GallowayManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Claire R CousinsSchool of Earth and Environmental Sciences, University of St Andrews, St Andrews, UK.
Franziska NagelManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Rainer BreitlingManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Eriko TakanoManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Snaedís Huld BjörnsdóttirSchool of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Sophie L NixonManchester Institute of Biotechnology, University of Manchester, Manchester, UK. sophie.nixon@manchester.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/V00560X/1Royal Society RGS\R2\222350UK Space Agency ST/W002337/1
6 · The paper itself

Abstract

backgroundTerrestrial hot springs are extreme environments shaped by geothermal heat, geogenic gases and extremes of pH and temperatures. Their gas fluxes, which include CO

resultsWe conducted comparative analysis of 73 worldwide hot spring metagenomes, spanning a wide range of environmental conditions (pH 1.5-10.0, temperatures 25-98 °C). By taking a gene-centric approach to whole communities, we show that hot spring microbiomes ubiquitously encoded carbon fixation pathways and biosynthetic genes (and gene clusters) for the synthesis of value-added products, regardless of geographical location and pH-temperature conditions. Candidate value-added products include platform chemicals such as acetone, lactic acid, and 1,2-propanediol, as well as high-value biomolecules including B vitamins and alginate.

conclusionsThis first biotechnology-focused assessment of hot spring microbiomes demonstrates that these communities encode the genomic potential to support novel, ex situ microbial platforms for upgrading CO SIGNIFICANCE: Industrial CO

Indexed as

Biosynthetic gene clustersChemolithoautotrophyCO2 utilisationComparative metagenomicsHot spring microbiomesMicrobiome engineering

Identifiers

PMID41814441
PMCPMC13093976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.