Evidence map›Paper›PMID 41814306›Full record

ArticleJournal of biomedical science2026

Disruption of primary ciliary prostaglandin E

Huan-Tzu Hou, Wan-Ning Li, Ting-Chien Lin, Chih-Wei Lin, Po-Hung Pan, Chih-Jhen Lee, Yi-Chen Chen, Po-Fan Chen, Chia-Yih Wang, Meng-Hsing Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huan-Tzu HouInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wan-Ning LiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ting-Chien LinDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan.
Chih-Wei LinDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan.
Po-Hung PanDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan.
Chih-Jhen LeeInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yi-Chen ChenDepartment of Physiology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan.
Po-Fan ChenDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan.
Chia-Yih WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Meng-Hsing WuDepartment of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan. mhwu68@mail.ncku.edu.tw.
Shaw-Jenq TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. seantsai@ccu.edu.tw.

Funding

National Science and Technology Council NSTC 112-2320-B-006-019-MY3
6 · The paper itself

Abstract

backgroundInfertility affects one in six individuals worldwide despite the advancement of assisted reproductive technologies. Successful embryo implantation is the first step of pregnancy, which relies on the establishment of a receptive uterine microenvironment. However, the mechanisms governing uterine receptivity and implantation failure remain incompletely characterized. Primary cilia serve as key cellular signaling hubs, yet their contribution to human decidualization and uterine receptivity remains largely unexplored.

methodsPrimary cultured human endometrial stromal cells (ESCs) were used to investigate the mechanisms of decidualization, functions of primary cilia, and effects of transforming growth factor-β (TGF-β) in inhibiting prostaglandin E

resultsProstaglandin E

conclusionsEndometrial primary cilia are indispensable for decidualization and are potential biomarkers for predicting endometrial receptivity. Targeting TGF-β signaling to restore ciliated cell number and ciliary length may serve as a potential therapeutic strategy to improve fertility outcomes.

Indexed as

CiliaDinoprostoneEmbryo ImplantationEndometriumSignal TransductionTransforming Growth Factor beta1AdultAnimalsFemaleHumansMicePregnancyStromal CellsDinoprostoneTransforming Growth Factor beta1DecidualizationEndometriosisInfertilityPGE2Primary ciliaTGF-β1

Identifiers

PMID41814306
PMCPMC12980961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.