Observational studyBMC pregnancy and childbirth2026
Impact of inactivated SARS-CoV-2 vaccination on blastocyst euploidy status: a prospective cohort study of patients undergoing preimplantation genetic testing for aneuploidy in China.
Observational study in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
Funding
Abstract
research questionIs there a difference in the euploidy status and pregnancy outcomes among patients undergoing preimplantation genetic testing for aneuploidy (PGT-A) inoculated with inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine?
designFrom January 2022 to February 2023, patients undergoing the first cycle of PGT-A treatment at the Reproductive Medicine Center of Sichuan Provincial Women’s and Children’s Hospital were prospectively enrolled. The patients were divided into vaccinated group (n = 214) and unvaccinated group (n = 176) based on inoculation of inactivated SARS-CoV-2 vaccines before ovarian stimulation (OS). The primary outcome was euploidy blastocyst rate.
resultsThe euploidy rate per blastocyst undergone PGT-A (51.14% vs. 55.88%), proportion of cycles with euploidy blastocyst in PGT-A and OS cycles were not significantly different between the vaccinated and unvaccinated groups (P > 0.05). The rates of embryo implantation, clinical pregnancy, spontaneous abortion and live birth, gestational age at delivery, birth weight and height of infants from frozen-thawed embryo transfer (FET) cycle were not significantly different between the two groups (P > 0.05).
conclusionInactivated SARS-CoV-2 vaccine may not affect the euploidy status and outcomes of FET among patients undergoing PGT-A. CLINICAL
trial registrationChinese Clinical Trial Registry. ChiCTR2200055721, https://www.chictr.org.cn/bin/project/edit?pid=148,254 , 16 January 2022.
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