Evidence map›Paper›PMID 41814192›Full record

Trial reportBMC geriatrics2026

Application of lower limb exoskeleton robots in elderly patients with ICU-acquired weakness: a prospective clinical study.

Xing Jin, Xiu-Rong Wang, Kui Wang, Meng-Yi Ren, Kang Yang, Bo Chen, Daejung Yang, Zhao-Xiang Meng

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xing Jin *Rehabilitation Medicine Department, Yangzhou Second People's Hospital, Yangzhou, Jiangsu, 225001, China.
Xiu-Rong Wang *Blood Purification Center, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225000, China.
Kui WangRehabilitation Medicine Department, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225000, China.
Meng-Yi RenRehabilitation Medicine Department, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225000, China.
Kang YangRehabilitation Medicine Department, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225000, China.
Bo ChenRehabilitation Medicine Department, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225000, China.
Daejung Yang *Department of Physical Therapy, Sehan University, Mokpo, Jeollanam-do, 58447, Republic of Korea. pt6226@sehan.ac.kr.
Zhao-Xiang Meng *Rehabilitation Medicine Department, Yangzhou Second People's Hospital, Yangzhou, Jiangsu, 225001, China. yzmzx001@163.com.

Funding

General project of Jiangsu Provincial Health Commission NO. H2023006Supportive technology project of Northern Jiangsu People's Hospital NO.FCJS202563Yangzhou Basic Research Program (Joint Special Project) NO.2024-2-16
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the application effects of lower-limb exoskeleton robots in elderly patients with intensive care unit-acquired weakness (ICU-AW).

methodsA total of 114 elderly patients with ICU-AW admitted to Yangzhou Second People’s Hospital between May 2023 and May 2025 were enrolled and randomly assigned using a random number table to either a control group (n = 57) or an experimental group (n = 57). The control group received conventional rehabilitation interventions, while the experimental group underwent lower-limb exoskeleton robot-assisted training in addition to conventional rehabilitation. Outcome measures compared before and after the intervention included scores on the Chelsea Critical Care Physical Assessment Tool (CPAx), Medical Research Council (MRC) muscle strength scale, and Barthel Index (BI); muscle quality parameters (fat fraction, cross-sectional area, T2 mapping); bone mineral density (T-score and classification); serum levels of creatine kinase (CK), osteocalcin (OC), and alkaline phosphatase (ALP); and the incidence of complications.

resultsCompared with baseline, both groups showed significant increases in CPAx, MRC, and BI scores, muscle cross-sectional area, T-scores, and serum OC levels, along with significant decreases in fat fraction, muscle water content T2, prevalence of osteoporosis, and serum CK and ALP levels (all P < 0.05). The improvements in all these outcome measures were significantly greater in the experimental group than in the control group (all P < 0.05). The overall complication rate was significantly lower in the experimental group [7.02% (4/57)] compared with the control group [21.05% (12/57)] (P = 0.031).

conclusionRehabilitation training using a lower-limb exoskeleton robot effectively improved muscle quality and bone mineral density in patients with ICU-AW, promoted physical functional recovery, enhanced quality of life, and demonstrated a favorable safety profile.

Indexed as

Exoskeleton DeviceIntensive Care UnitsLower ExtremityMuscle WeaknessRoboticsAgedAged, 80 and overFemaleHumansMaleMuscle StrengthProspective StudiesAgedBone densityCritical illness polyneuropathyMuscle weaknessRehabilitationRobotics

Identifiers

PMID41814192
PMCPMC13088658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.