Evidence map›Paper›PMID 41814152›Full record

ArticleBMC genomics2026

Matrix metalloproteinase 2 governs extracellular matrix remodeling during ovarian development in a viviparous teleost Sebastes schlegelii (Hilgendorf, 1880).

Fengyan Zhang, Xinyi Wang, Hanwei Zheng, Yiyang Shen, Ruiyan Yang, Xiangyu Gao, Yan He, Weihao Song

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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fengyan ZhangMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Xinyi WangMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Hanwei ZhengMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Yiyang ShenMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Ruiyan YangMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Xiangyu GaoMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Yan HeMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China.
Weihao SongMOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, 266000, China. songweihao8@163.com.

Funding

Hainan Seed Industry Laboratory project B24C1000103National Natural Science Foundation of China 32370564
6 · The paper itself

Abstract

backgroundSebastes schlegelii (Hilgendorf, 1880), a viviparous fish with annual ovarian remodeling, shows marked activation of Extracellular Matrix (ECM)-receptor interaction signaling post-mating. However, the evolutionary conservation and functional significance of a key ECM remodeler-Matrix metalloproteinase 2 (MMP2) in this unique reproductive system are poorly understood.

resultsIn this study, we identified the core members of the MMP family from the S. schlegelii genome and investigated their expression patterns and localization in ovarian tissues. The results demonstrated that the gelatinase gene mmp2 (Ssc_10020200) displayed high expression levels in the mated ovaries, with its expression being predominantly located in the ovarian follicular cell layers and follicular placenta and embryos. Both in vitro and in vivo experiments revealed that MMP2 knockdown during the vitellogenic and gestation stages led to significant ovarian developmental abnormalities. Furthermore, MMP2 knockdown induced a reduction in ECM components such as COL4Α1, LAMB1, and FN1B, accompanied by enhanced apoptotic signaling.

conclusionsThis study suggests that MMP2 plays a vital role in modulating ECM remodeling and maintaining ovarian tissue homeostasis, further ensuring normal ovarian development and healthy reproductive processes. Our findings elucidate a critical function for MMP2 in ovarian development of viviparous teleost, and may inspire further strategies to enhance fish reproductive health and aquaculture outcomes.

Indexed as

Extracellular MatrixFishesMatrix Metalloproteinase 2OvaryAnimalsFemaleGene Expression Regulation, DevelopmentalPhylogenyViviparity, NonmammalianMatrix Metalloproteinase 2Extracellular matrix remodelingMatrix metalloproteinase 2Ovarian developmentSebastes schlegeliiViviparity

Identifiers

PMID41814152
PMCPMC13088543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.