Evidence map›Paper›PMID 41814084›Full record

ReviewDiscover oncology2026

Implications for clinical prognosis and target discovery of the SWI/SNF complex in genitourinary tumors.

Zheng Tang, Haodong Chi, Weiguang Zhao, Renjie Wang, Yin Yang, Zijie Xu, Zetao Ding, Kaiying Chen, Junru Lu, Sang Hu and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zheng Tang *Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Haodong Chi *Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Weiguang ZhaoDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Renjie WangDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Yin YangDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Zijie XuDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Zetao DingDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Kaiying ChenDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Junru LuDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China.
Sang HuCentral Hospital of Haining, 758 Chang'an Road, Chang'an Town, Haining, Zhejiang, China.
Zhixian YaoDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Rd, Shanghai, 200120, China. yzxbrooklyn@sjtu.edu.cn.
Zhihong LiuDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Rd, Shanghai, 200080, China. drzhihongliu@sjtu.edu.cn.

Funding

Natural Science Foundation of China NO. 82072823Shanghai Municipal Health Commission NO. 202240245
6 · The paper itself

Abstract

Dysregulation of chromatin is considered one of the root causes of tumor occurrence and progression. In the past two decades, the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, a crucial player in chromatin remodeling, has emerged as a significant focus of cancer research and has been found to play a pivotal role in cancer development and progression through the regulation of the expression of cancer-related genes. Notably, studies have unveiled that genetic mutations and functional alterations in the SWI/SNF complex subunits, such as ARID1A, are prevalent across a broad spectrum of cancers, but the role of this complex in genitourinary neoplasms has not been systematically summarized yet. Therefore, in this review, we have summarized the mechanisms of SWI/SNF complex components in the occurrence and development of urological tumors. In addition, we have also discussed its clinical value and presented treatment strategies that target the SWI/SNF complex in order to provide a comprehensive overview of the status of current research and future areas of clinical focus in this field.

Indexed as

Chromatin remodelerGenitourinary neoplasmsSWI/SNF complexTumor prognosisTumor treatment

Identifiers

PMID41814084
PMCPMC13096368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.