Evidence map›Paper›PMID 41814078›Full record

ArticleNature metabolism2026

Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration.

Tao Yao, Xin Tian, Linbin Rao, Jinling Ni, Jiayong Yu, Hongguo Yang, Yuexiao Tang, Xingxiao Huang, Xintong Xia, Lin Zhao and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. A new era of lineage tracing.Cell research · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tao Yao *Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Xin Tian *Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Linbin RaoCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Jinling NiCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Jiayong YuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Hongguo YangDepartment of Hepatobiliary & Pancreatic Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Yuexiao TangZhejiang Key Laboratory of Disease-Syndrome Integration for Cancer Prevention and Treatment, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Xingxiao HuangZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Xintong XiaCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Lin ZhaoZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Bowen DiaoZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Yan PingZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0009-0006-4263-6930
Danni WeiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Siqi LiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Hui ChaiCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Zhiming HuDepartment of Hepatobiliary & Pancreatic Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Xiongzhong RuanCentre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0000-0001-5199-4971
Suihan FengState Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-9205-0050
Mengle ShaoState Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. mlshao@ips.ac.cn.ORCID http://orcid.org/0000-0002-5488-9904
Bo ShanZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China. boshan@zju.edu.cn.ORCID http://orcid.org/0000-0002-1675-5809
Ying WuZhejiang Key Laboratory of Disease-Syndrome Integration for Cancer Prevention and Treatment, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China. wuying@sibs.ac.cn.ORCID http://orcid.org/0009-0008-1808-3349

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFA1104102National Natural Science Foundation of China (National Science Foundation of China) 31900543National Natural Science Foundation of China (National Science Foundation of China) 32241008National Natural Science Foundation of China (National Science Foundation of China) 32371235National Natural Science Foundation of China (National Science Foundation of China) 32471175National Natural Science Foundation of China (National Science Foundation of China) 81972674National Natural Science Foundation of China (National Science Foundation of China) 82170891National Natural Science Foundation of China (National Science Foundation of China) 82270926
6 · The paper itself

Abstract

Tissue regeneration is essential for maintaining tissue homoeostasis and influences disease progression. In the liver, injury evokes a complex regenerative response with robust immune activation and metabolic rewiring, yet how these processes coordinate hepatocyte proliferation remains unclear. Here we show the presence of an injury-induced, lipid-dependent accrual of a distinct monocyte-derived macrophage (MDM) subset characterized by abundant cytosolic lipid content and heightened inflammatory response. Multi-omic analyses, spanning both single-cell transcriptomics and quantitative lipidomics, unveil substantial cellular diversity and heterogeneity between these 'lipo-inflammatory MDMs' (termed LIMMs) and other hepatic macrophages, including Kupffer cells. Blocking CD36-dependent LIMM induction markedly impairs hepatocyte proliferation and liver regeneration in injured livers. Mechanistically, CD36-mediated increase in ceramide biosynthesis activates IRE1α-XBP1 signalling pathway in LIMMs, driving production of the regenerative cytokine interleukin-6. Disrupting CD36-dependent IRE1α activation in LIMMs compromises liver repair. These findings identify a lipid-laden MDM subcluster as a key regulator of regenerative inflammation in injured livers.

Indexed as

Lipid MetabolismLiver RegenerationMacrophagesAnimalsCD36 AntigensCell ProliferationEndoribonucleasesHepatocytesLipidomicsLiverMaleMiceMice, Inbred C57BLProtein Serine-Threonine KinasesSignal TransductionX-Box Binding Protein 1CD36 AntigensEndoribonucleasesErn1 protein, mouseProtein Serine-Threonine KinasesX-Box Binding Protein 1

Identifiers

PMID41814078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.