Evidence map›Paper›PMID 41814056›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2026

Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.

Jena' N Mazique, Caroline Sit, Raven Riley, Zelma Iriarte Oporto, Ian Mcneill, Tianwen Chen, James Warren, David Huang, Youguo Xu, Austin Frisbie and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jena' N MaziqueProgram in Neuroscience, School of Graduate Study, University of Mississippi Medical Center, Jackson, MS, USA.
Caroline SitDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Raven RileyDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Zelma Iriarte OportoDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Ian McneillDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Tianwen ChenDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
James WarrenDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
David HuangDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Youguo XuDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Austin FrisbieDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Bradley WaltersDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Yi PangDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.
Wu ZhouDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. wzhou@umc.edu.
Hong ZhuDepartment of Otolaryngology-Head and Neck Surgery, Balance and Auditory Research Center (BARC), University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. hozhu@umc.edu.ORCID http://orcid.org/0000-0002-3944-4624

Funding

Renovation for Neurophysiology Core BP20GM156708 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI WU ZHOU · 2025 to 2026
$7.3M
Mechanisms of Blast-Induced Vestibular InjuryR01DC018919 · NIDCD · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHOU, WU, ZHU, HONG · 2020 to 2024
$3.0M
NIDCD NIH HHS R01 DC018919NIDCD NIH HHS R01DC018919NIGMS NIH HHS 1P20GM156708-01NIGMS NIH HHS P20 GM156708
6 · The paper itself

Abstract

purposeMilitary personnel and veterans exposed to blast overpressure waves frequently report vestibular symptoms, including dizziness, vertigo, and imbalance. Although blast exposure is known to disrupt vestibular function, how vestibular deficits develop over time, particularly at the level of vestibular afferent signaling, remains unclear.

methodsIn this study, we used an ear-blast model to investigate the early injury responses and progression of vestibular deficits following a single, moderate-intensity blast exposure (20 PSI) in male and female Long-Evans rats. Vestibular function was assessed using single-unit recordings from vestibular afferents and vestibulo-ocular reflex (VOR) testing.

resultsBlast exposure produced progressive changes in vestibular afferent activity in both male and female rats. In males, spontaneous firing rates remained unchanged, whereas females showed a reduction at 1 day and 14 days post-blast. In both sexes, firing irregularity increased, and a greater proportion of afferents became less responsive to head rotation and translation. Although gains and phases of the remaining canal and otolith afferents were preserved, response distortion increased following blast exposure, indicating reduced precision of vestibular afferents' encoding of head movement. Despite the impairments in vestibular nerve activity, steady-state rotational and translational VOR gains remained largely unchanged, with only moderate phase changes up to 56 days post-blast. However, a subset of animals exhibited reduced step rotational VOR gains and earlier quick phase responses following blast exposure. Morphological analysis revealed stereocilia damage, significant loss of saccular hair cells, and astrocytic activation in the central vestibular nuclei.

conclusionTogether, these findings indicate that blast-induced vestibular injury involves both peripheral and central components, with progressive changes in vestibular afferent activity that could influence sensory inputs to the CNS.

Indexed as

Blast InjuriesVestibule, LabyrinthAnimalsDisease ProgressionFemaleMaleRatsRats, Long-EvansReflex, Vestibulo-OcularBlast overpressureRatsVestibular afferentsVestibular deficitsVestibulo-ocular reflex (VOR)

Identifiers

PMID41814056
PMCPMC13095138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.