Evidence map›Paper›PMID 41814054›Full record

ArticleObesity surgery2026

miR-128-3p and miR-223-3p as Potential Biomarkers of Metabolic Dysfunction in Liver Tissue from Patients Undergoing Metabolic Bariatric Surgery.

Raquel Rodríguez, Daniel Salete-Granado, Lourdes Hernández-Cosido, María Teresa Cabero Morán, Oscar Blanco, Nuria Matesanz, Vanessa Rueda-Cala, Fabiola Campo, María-Ángeles Pérez-Nieto, Carlos Gutiérrez Cerrajero and 6 more

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In one paragraph

Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Raquel Rodríguez *Bariatric Surgery Unit. Department of General & Gastrointestinal Surgery, University Hospital of Salamanca-SACYL, Salamanca, Spain.
Daniel Salete-Granado *University of Salamanca, Salamanca, Spain.
Lourdes Hernández-CosidoBariatric Surgery Unit. Department of General & Gastrointestinal Surgery, University Hospital of Salamanca-SACYL, Salamanca, Spain.
María Teresa Cabero MoránUniversity of Salamanca, Salamanca, Spain.
Oscar BlancoUniversity of Salamanca, Salamanca, Spain.
Nuria MatesanzDepartment of Vascular Biology and Inflammation, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III,, Madrid, Spain.
Vanessa Rueda-CalaInstitute of Biomedical Research of Salamanca, Salamanca, Spain.
Fabiola CampoDepartment of Internal Medicine, University Hospital of Salamanca-SACYL, Salamanca, Spain.
María-Ángeles Pérez-NietoUniversity of Salamanca, Salamanca, Spain.
Carlos Gutiérrez CerrajeroUniversity of Salamanca, Salamanca, Spain.
Edgar BernardoDepartment of Vascular Biology and Inflammation, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III,, Madrid, Spain.
Ronald MacíasDepartment of Internal Medicine, Complejo Asistencial de Zamora-SACYL, Zamora, Spain.
Guadalupe SabioDepartment of Vascular Biology and Inflammation, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III,, Madrid, Spain.
Jorge-Luis TorresDepartment of Internal Medicine, Complejo Asistencial de Zamora-SACYL, Zamora, Spain.
Maura Rojas-Pirela *Institute of Biomedical Research of Salamanca, Salamanca, Spain. mrojaspirela@usal.es.
Miguel Marcos *Institute of Biomedical Research of Salamanca, Salamanca, Spain. mmarcos@usal.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsWe quantified the expression levels of four miRNAs (hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-223-3p, and hsa-let-7a) in liver samples obtained during bariatric metabolic surgery from patients with obesity and healthy controls using qPCR. Expression was normalized to hsa-miR-24-3p, selected as the most stable reference gene in our cohort. Associations between miRNA levels and clinical or demographic variables (sex, AMPs) were also explored.

resultsCompared with controls, patients with obesity showed significant dysregulation of hsa-miR-128-3p and hsa-miR-223-3p, independent of histological liver alterations. No consistent changes were observed for hsa-miR-21-3p or hsa-let-7a. Clinical variables, including AMPs, did not account for the observed differences.

conclusionmiR-128-3p and miR-223-3p are linked to obesity-related metabolic dysfunction and emerge as promising biomarkers or therapeutic targets.

Indexed as

Bariatric SurgeryLiverMicroRNAsObesity, MorbidAdultBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedBiomarkersMicroRNAsMIR223, humanMIRN128 microRNA, humanAssociated medical problemLiverMiRNAObesityPrognostic and therapeutic tools

Identifiers

PMID41814054
PMCPMC13083441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.