Evidence map›Paper›PMID 41814011›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis.

Martí Oró-Nolla, Melody Cui Sun, Thomas Reilly, Julia Anandarajah, Almudena Otálora-Alcaraz, Lisa Costelloe, Hugh Kearney, Richard Magee, Yvonne M Nolan, Eric J Downer

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martí Oró-NollaDiscipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Melody Cui SunDiscipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Thomas ReillyDiscipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Julia AnandarajahDiscipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Almudena Otálora-AlcarazDiscipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Lisa CostelloeDepartment of Neurology, Beaumont Hospital, Dublin, Ireland.
Hugh KearneyMS Unit, Department of Neurology, St. James's Hospital, Dublin, Ireland.
Richard MageeDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Yvonne M NolanDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Eric J DownerDiscipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. edowner@tcd.ie.ORCID http://orcid.org/0000-0002-6012-2291

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDual-specificity phosphatase 1 (DUSP1) is a negative regulator of mitogen-activated protein kinase (MAPK) activity, and a player in the control of glial function. Several disease models have identified that the expression of DUSP1 is altered in tissue samples, which may contribute to disease pathogenesis. Using post-mortem brain tissue from a cohort of progressive multiple sclerosis (MS) cases, this study set out to determine if the expression of DUSP1 is altered in the brain in MS.

methodsWe employed the use of a combination of PCR, western immunoblotting and immunohistochemical analysis to profile the expression of DUSP1.

resultsData presented herein indicate that DUSP1 is significantly downregulated at gene and protein level in MS white matter tissue, when compared to samples from a non-MS control cohort. We also identify that DUSP1 is expressed on Iba1+ cells in the brain and that ITGAM (CD11b) expression is elevated in white matter in progressive MS.

conclusionsThese findings provide evidence that DUSP1 is dysregulated centrally in CNS white matter in progressive MS.

Indexed as

BrainDual Specificity Phosphatase 1Multiple Sclerosis, Chronic ProgressiveWhite MatterAgedDown-RegulationFemaleHumansMaleMicrofilament ProteinsMicrogliaMiddle AgedRNA, MessengerDual Specificity Phosphatase 1DUSP1 protein, humanMicrofilament ProteinsRNA, MessengerDUSP1Microglia/macrophagesMultiple sclerosisWhite matter

Identifiers

PMID41814011
PMCPMC12979298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.