Evidence map›Paper›PMID 41813933›Full record

ArticleScientific reports2026

1,2-propanediol ameliorated radiation-induced intestinal injury in mice.

Jiwei Zhao, Chunan Zhao, Xing Shen, Ying Jiang, Xun Wang, Aoqiang Ji, Xuewen Zhang, Shuang Xing, Gang Sun, He Xiao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiwei Zhao *Academy of Military Medical Sciences, Beijing, 100850, China.
Chunan Zhao *Academy of Military Medical Sciences, Beijing, 100850, China.
Xing Shen *Academy of Military Medical Sciences, Beijing, 100850, China.
Ying JiangAcademy of Military Medical Sciences, Beijing, 100850, China.
Xun WangAcademy of Military Medical Sciences, Beijing, 100850, China.
Aoqiang JiAcademy of Military Medical Sciences, Beijing, 100850, China.
Xuewen ZhangAcademy of Military Medical Sciences, Beijing, 100850, China.
Shuang XingAcademy of Military Medical Sciences, Beijing, 100850, China.
Gang SunDepartment of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing, 100583, China. sunok301@126.com.
He XiaoAcademy of Military Medical Sciences, Beijing, 100850, China. crocodilexiao@sina.com.
Zuyin YuAcademy of Military Medical Sciences, Beijing, 100850, China. yuzy79@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is constricted by collateral normal tissue injury during treatment, particularly the gastrointestinal tracts, which is usually referred as radiation-induced gastrointestinal syndrome (RIGS). Currently, there is no FDA-approved agent for the prevention or treatment of RIGS. By using a mice model of RIGS, we demonstrated that 1,2-propanediol (1,2-PD) prevents radiation-induced fatal intestinal injury and significantly increases mice survival following lethal doses of radiation. 1,2-PD pretreatment also enhanced the survival of Lgr5

Indexed as

IntestinesPropylene GlycolRadiation InjuriesRadiation Injuries, ExperimentalRadiation-Protective AgentsAnimalsApoptosis Regulatory ProteinsBasic Helix-Loop-Helix ProteinsCell Cycle CheckpointsDNA DamageEndothelial PAS Domain-Containing Protein 1EnterocytesMicePPAR alphaReceptors, G-Protein-CoupledSignal TransductionApoptosis Regulatory ProteinsBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Lgr5 protein, mousePPAR alphaPropylene GlycolPUMA protein, mouseRadiation-Protective AgentsReceptors, G-Protein-CoupledTumor Suppressor Protein p53Tumor Suppressor Proteins

Identifiers

PMID41813933
PMCPMC13100010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.