Evidence map›Paper›PMID 41813902›Full record

ArticleNature2026

The dynamic basis of G-protein recognition and activation by a GPCR.

Kazuhiro Kobayashi, Kouki Kawakami, Toshiki E Matsui, Shun Yokoi, Masahiro Fukuda, Tomohiro J Narita, Hiroki Arai, Mai Tambo, Takashi Sumikama, Manae Tatsumi and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kazuhiro Kobayashi *Research Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.ORCID http://orcid.org/0000-0002-3366-3586
Kouki Kawakami *Research Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.ORCID http://orcid.org/0000-0002-2507-8619
Toshiki E Matsui *Research Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.
Shun Yokoi *Department of Physics, School of Science and Technology, Meiji University, Kawasaki, Japan.
Masahiro FukudaResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.ORCID http://orcid.org/0000-0002-8824-846X
Tomohiro J NaritaResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.
Hiroki AraiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Mai TamboLaboratory of Biomolecular Dynamics at Nanoscale, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Takashi SumikamaLaboratory of Biomolecular Dynamics at Nanoscale, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-3696-5720
Manae TatsumiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Keitaro YamashitaResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.ORCID http://orcid.org/0000-0002-5442-7582
Junki KoyanagiResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.
Mai KugawaResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.
Hisako IkedaResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan.
Ayumi SuminoLaboratory of Biomolecular Dynamics at Nanoscale, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Ayori MitsutakeDepartment of Physics, School of Science and Technology, Meiji University, Kawasaki, Japan.ORCID http://orcid.org/0000-0002-4194-7255
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5958-3990
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.ORCID http://orcid.org/0000-0003-0805-4049
Hideaki E KatoResearch Center for Advanced Science and Technology, The University of Tokyo, Meguro, Japan. c-hekato@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-1941-5535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-protein-coupled receptor (GPCR) signalling occurs through heterotrimeric G proteins, whose selective activation leads to distinct cellular outcomes

Indexed as

Cryoelectron MicroscopyGTP-Binding ProteinsReceptors, G-Protein-CoupledReceptors, NeurotensinGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11Guanosine DiphosphateGuanosine TriphosphateHumansKineticsModels, MolecularProtein BindingSignal TransductionGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsGuanosine DiphosphateGuanosine Triphosphateneurotensin type 1 receptorReceptors, G-Protein-CoupledReceptors, Neurotensin

Identifiers

PMID41813902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.