Evidence map›Paper›PMID 41813901›Full record

ArticleNature2026

Natural maternal immunity protects neonates from Escherichia coli sepsis.

Raymond E Diep, Ujjwal Adhikari, Kubra Gokce Tezel, Giang Pham, Allison R Burrell, Mary A Staat, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Kate M Peters, Mark A Schembri and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Article
  6. Rethinking neonatalFrontiers in immunology · 2026
    Article
  7. Research Progress on perinatalFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Raymond E DiepDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ujjwal AdhikariDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kubra Gokce TezelDivision of Neonatology, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Giang PhamDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Allison R BurrellDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Mary A StaatDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nguyen Thi Khanh NhuInstitute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, Queensland, Australia.
Minh-Duy PhanInstitute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-3426-1044
Kate M PetersInstitute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, Queensland, Australia.
Mark A SchembriInstitute for Molecular Bioscience (IMB), The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4863-9260
Scott H SaundersLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
David B HaslamDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
John J EricksonDivision of Neonatology, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-6189-9302
Susana Chavez-BuenoDivision of Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, MO, USA.ORCID http://orcid.org/0000-0001-8371-5463
Sing Sing WayDivision of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. singsing.way@cchmc.org.

Funding

Vertically transferred antibodies protect babies from Escherichia coli infectionR01AI189741 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2025 to 2025
$2.8M
Pregnancy induced deacetylation of sialylated glycoproteinsR01AI175431 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Sing Sing Way · 2024 to 2026
$2.3M
Parity, paternity and pregnancy outcomesR01AI184537 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Sing Sing Way · 2024 to 2026
$1.8M
NIAID NIH HHS R01 AI175431NIAID NIH HHS R01 AI184537NIAID NIH HHS R01 AI189741
6 · The paper itself

Abstract

Escherichia coli is a leading cause of neonatal sepsis, with infection occurring in approximately one in every 1,000 live births

Indexed as

Escherichia coliEscherichia coli InfectionsImmunity, Maternally-AcquiredNeonatal SepsisSepsisAnimalsAnimals, NewbornAntibodies, BacterialBacterial Outer Membrane ProteinsCross ReactionsFemaleHumansImmunoglobulin GInfant, NewbornMaleMiceAntibodies, BacterialBacterial Outer Membrane ProteinsImmunoglobulin GOMPA outer membrane proteinsReceptors, Fc

Identifiers

PMID41813901
PMCPMC13108393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.