ArticleNature2026
B cell imprinting in children impairs antibodies to the haemagglutinin stalk.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- What Antibody Repertoires See: Structural and Immunogenetic Insights Into Influenza A Virus Hemagglutinin Recognition.Immunological reviews · 2026Review
- From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses.Journal of virology · 2026Review
- Influenza.Nature reviews. Disease primers · 2026Review
- Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies.Immunological reviews · 2026Review
- The Influenza-Specific Immunoglobulin Repertoire - Nimble Yet Steeped in Tradition.Immunological reviews · 2026Review
- Mechanisms Underlying the Induction of Immunological Imprinting by RNA Viruses and Intervention Strategies.Viruses · 2026Review
- Age-dependent immune landscapes affect influenza vaccine effectiveness and guide precision strategies.Frontiers in immunology · 2026Review
Corrections and comments
- Update of
Authors and funding
37 authors.
Jiayi Sun *Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Gyunghee Jo *Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7221-2561
Chloe A TroxellDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0003-9647-324X
Yanbin FuDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Robert HoezlDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0009-2536-8219
Huibin LvDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0003-2218-0076
Hassanein H AbozeidInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5433-6939
Qi Wen TeoDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Tossapol PholchareeDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Joshua J C McGrathDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-9267-5501
Siriruk ChangrobDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1826-4333
Sean A NelsonDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Atsuhiro YasuharaDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Min HuangDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Nai-Ying ZhengDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Jordan C ChervinDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Lei LiDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Monica L Fernández-QuinteroDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Johannes R LoefflerDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Alesandra J RodriguezDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Jiachen HuangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Olivia M SwansonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8162-8358
Angel BalmasedaSustainable Sciences Institute, Managua, Nicaragua.
Guillermina KuanSustainable Sciences Institute, Managua, Nicaragua.
Lora CampredonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
E Kaitlynn AllenDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-3067-751X
Gabriele NeumannInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Nicholas C WuDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-9078-6697
Yoshihiro KawaokaInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-5061-8296
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4121-776X
Asuncion MejiasCenter for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Octavio RamiloCenter for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0565-5239
Paul G ThomasDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7955-0256
Aubree GordonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9352-7877
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7153-3769
Julianna HanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3402-2609
Patrick C WilsonDrukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. pcw4001@med.cornell.edu.ORCID http://orcid.org/0000-0002-3537-1245
Funding
Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7MProject 2U19AI168632 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Octavio Ramilo · 2022 to 2026
$10.2MA deep longitudinal analysis of next generation influenza vaccines in older adultsU01AI165452 · NIAID · JACKSON LABORATORY · PI Adolfo Garcia-Sastre, GEORGE A KUCHEL · 2022 to 2026
$9.0MComputational Models of Adaptive Immunity to InfluenzaU01AI187063 · NIAID · UNIVERSITY OF CHICAGO · PI Sarah Cobey · 2025 to 2026
$2.4MNIAID NIH HHS U01 AI144616NIAID NIH HHS U01 AI165452NIAID NIH HHS U01 AI187063NIAID NIH HHS U19 AI168632
Abstract
Immune imprinting
Indexed as
Antibodies, ViralB-LymphocytesHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeAdultAntibodies, NeutralizingChildChild, PreschoolCross ReactionsEpitopesFemaleHumansImmunologic MemoryInfantInfluenza, HumanAntibodies, NeutralizingAntibodies, ViralEpitopesHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines
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Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.