Evidence map›Paper›PMID 41813890›Full record

ArticleNature2026

Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.

Qinli Sun, Alison K Barrett, Masato Ogishi, Huiyun Lyu, Hua Jiang, Honghui Liu, Yang Zhao, Grayson E Rodriguez, Pingdong Tao, Matthias Obenaus and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qinli SunDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1220-3388
Alison K BarrettInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0009-0007-4570-5265
Masato OgishiDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2421-7389
Huiyun LyuDiabetes Center, University of California, San Francisco, CA, USA.
Hua JiangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Honghui LiuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Yang ZhaoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6596-499X
Grayson E RodriguezDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0009-0002-7386-2050
Pingdong TaoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Matthias ObenausDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Karsten D HouseholderDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0282-4479
Qizhi TangDiabetes Center, University of California, San Francisco, CA, USA.
Tobias V LanzInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7106-8801
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.ORCID http://orcid.org/0000-0001-9273-0278

Funding

Genetic and immunological dissection of coinhibitory crosstalks between human T cells and cancer cellsK00CA274708 · NCI · STANFORD UNIVERSITY · PI Masato Ogishi · 2024 to 2026
$297k
NCI NIH HHS K00 CA274708
6 · The paper itself

Abstract

CD4

Indexed as

Immune ToleranceInterleukin-2Transforming Growth Factor betaAnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleMaleMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinNuclear Receptor Subfamily 1, Group F, Member 3OvalbuminReceptors, Interleukin-2Signal TransductionSmad2 ProteinSmad3 ProteinInterleukin-2Myelin-Oligodendrocyte GlycoproteinNuclear Receptor Subfamily 1, Group F, Member 3OvalbuminReceptors, Interleukin-2Smad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseSTAT5 Transcription FactorTransforming Growth Factor beta

Identifiers

PMID41813890
PMCPMC13190267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.