Evidence map›Paper›PMID 41813887›Full record

ArticleNature2026

Immune evasive DNA donors and recombinases license kilobase-scale writing.

Connor J Tou, Keqiang Xie, Joana Ferreira da Silva, Pazhanichamy Kalailingam, Eliz Amar-Lewis, David Rufino-Ramos, William Sawyer, Madeline L Eller, Jakob Starzyk, Ishita Majumdar and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Gene editing using large insertions.Nature biotechnology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Immune-evasive DNA integration with INSTALL.Nature reviews. Genetics · 2026
    Article
  8. Article
  9. Ultra-large targeted DNA integrations in primary human cells.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Connor J Tou *Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. connorjtou@gmail.com.ORCID http://orcid.org/0000-0003-2444-4215
Keqiang Xie *Full Circles Therapeutics, Cambridge, MA, USA.ORCID http://orcid.org/0009-0007-8320-5165
Joana Ferreira da SilvaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pazhanichamy KalailingamCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Eliz Amar-LewisInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9552-9780
David Rufino-RamosCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
William SawyerDepartment of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Madeline L EllerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0004-6484-0727
Jakob StarzykFull Circles Therapeutics, Cambridge, MA, USA.ORCID http://orcid.org/0009-0009-1559-6664
Ishita MajumdarFull Circles Therapeutics, Cambridge, MA, USA.
Jiao WangFull Circles Therapeutics, Cambridge, MA, USA.
Danna LeeFull Circles Therapeutics, Cambridge, MA, USA.
Shaobo YangDepartment of Bioengineering, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0009-0006-5257-6775
Ronald J MeisCELLSCRIPT, Madison, WI, USA.
Gary A DahlCELLSCRIPT, Madison, WI, USA.
Jiahe LiDepartment of Bioengineering, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9889-8546
Richard ShanFull Circles Therapeutics, Cambridge, MA, USA.
Natalie ArtziInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Patricia L MusolinoCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8724-5649
Hao WuFull Circles Therapeutics, Cambridge, MA, USA. howard.wu@fullcirclestx.com.ORCID http://orcid.org/0009-0002-3249-2428
Benjamin P KleinstiverCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5469-0655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-editing technologies that use recombinases to insert kilobase-scale DNA sequences into mammalian genomes canonically require large double-stranded DNA (dsDNA) donors

Indexed as

DNAGene EditingGenome, HumanRecombinasesAnimalsCRISPR-Cas SystemsDNA, CircularDNA, Single-StrandedFemaleHEK293 CellsHumansImmunity, InnateMaleMiceDNADNA, CircularDNA, Single-StrandedRecombinases

Identifiers

PMID41813887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.