A new multi-residue method for PFAS analysis in wastewater for environmental and public health risk assessment.

Dalia Elabbadi, Harry Elliss, Megan Robertson, John Bagnall, Barbara Kasprzyk-Hordern

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Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Dalia ElabbadiDepartment of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Harry EllissDepartment of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Megan RobertsonCentre of Excellence in Water-Based Early-Warning Systems for Health Protection, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

John BagnallCentre of Excellence in Water-Based Early-Warning Systems for Health Protection, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Barbara Kasprzyk-HordernDepartment of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. Bkh20@bath.ac.uk.

Funding

Natural Environment Research Council NE/X015890/1

6 · The paper itself

Abstract

This work focuses on the detection and quantification of per-/polyfluorinated alkyl substances (PFAS) in influent wastewater, using wastewater-based epidemiology via a new multi-residue ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. This covers a range of PFAS classes including perfluoroalkyl carboxylic acids (e.g. PFHxA), perfluoroalkyl sulfonic acids (e.g. PFBS), precursors (e.g. EtFOSAA), perfluoroalkyl phosphonic (e.g. PFOPA) and phosphinic acids (e.g. PFPiA), and novel PFAS (e.g. Gen X). Weak-anion exchange (WAX) cartridges and hydrophilic-lipophilic balance (HLB) solid-phase extraction cartridges for sample preparation were compared, with higher intensities and recoveries seen for different compounds for both cartridges. Method detection limits ranged from 0.03 (PFBS) to 756.9 ng L

Indexed as

FluorocarbonsWastewaterWater Pollutants, ChemicalChromatography, High Pressure LiquidEnvironmental MonitoringHumansLimit of DetectionLiquid Chromatography-Mass SpectrometryPublic HealthRisk AssessmentSolid Phase ExtractionTandem Mass SpectrometryFluorocarbonsWastewaterWater Pollutants, ChemicalLC-MS/MSPer-/polyfluorinated alkyl substancesPFAS adsorbanceWastewater

Identifiers

PMID41813875

DOI10.1007/s00216-026-06421-5

PMCPMC13079494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.