Evidence map›Paper›PMID 41813823›Full record

ArticleNPJ precision oncology2026

Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics.

Nona Struyf, Henrik Gezelius, Anders Lundmark, Chiara Barizza, Hidde Ploeger, Lucia Rico Pizarro, Mattias Vesterlund, Georgios Mermelekas, Albin Österroos, Anna Bohlin and 11 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nona StruyfDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden. nona.struyf@ki.se.
Henrik GezeliusDepartment of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Anders LundmarkDepartment of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Chiara BarizzaDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Hidde PloegerDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Lucia Rico PizarroDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Mattias VesterlundDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Georgios MermelekasDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Albin ÖsterroosDepartment of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
Anna BohlinDepartment of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
Sofia BengtzénDepartment of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
Kerstin Hamberg LevedahlDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Rozbeh JafariDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Lukas M OrreDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Janne LehtiöDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Päivi ÖstlingDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Brinton Seashore-LudlowDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Jessica NordlundDepartment of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Sören LehmannDepartment of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
Olli KallioniemiDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Tom ErkersDepartment of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden. tom.erkers@ki.se.

Funding

Barncancerfonden TJ2021-0080Karolinska Institutet 2024-00304Knut och Alice Wallenbergs Stiftelse 2015.0291Stiftelsen för Strategisk Forskning SB16-0058Vetenskapsrådet 2017-06095
6 · The paper itself

Abstract

FLT3-mutated acute myeloid leukemia (AML) remains difficult to treat due to frequent resistance to FLT3 inhibitors like midostaurin. In this study, we observed a progenitor-like CD38

Identifiers

PMID41813823
PMCPMC12996285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.