Evidence map›Paper›PMID 41813804›Full record

ArticleNature biomedical engineering2026

DNA origami vaccine nanoparticles improve humoral and cellular immune responses to infectious diseases.

Yang C Zeng, Olivia J Young, Qiancheng Xiong, Longlong Si, Min Wen Ku, Sylvie G Bernier, Hawa Dembele, Giorgia Isinelli, Tal Gilboa, Zoe Swank and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. DNA Nanostructures for siRNA Delivery.Bioconjugate chemistry · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Yang C Zeng *Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. yang_zeng@dfci.harvard.edu.ORCID http://orcid.org/0000-0003-0566-4976
Olivia J Young *Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2252-6623
Qiancheng Xiong *Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9897-7391
Longlong Si *Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0504-1659
Min Wen Ku *Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Sylvie G BernierWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Hawa DembeleDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Giorgia IsinelliDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1798-1576
Tal GilboaWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Zoe SwankWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Su Hyun SeokDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Anjali RajwarWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Amanda JiangWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Yunhao ZhaiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7826-217X
LaTonya D WilliamsCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8064-8533
Caleb A HellmanCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.
Chris M WintersingerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Amanda R GravelineWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Andyna VernetWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Melinda SanchezWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Sarai BardalesWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Georgia D TomarasCenter for Human Systems Immunology, Departments of Surgery and Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.
Ju Hee RyuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3422-3272
Ick Chan KwonDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1272-7074
Girija GoyalWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. girija.goyal@wyss.harvard.edu.ORCID http://orcid.org/0000-0002-2163-2205
Donald E IngberWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. don.ingber@wyss.harvard.edu.ORCID http://orcid.org/0000-0002-4319-6520
William M ShihDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. william_shih@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-1395-9267

Funding

Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) INV-002274National Research Foundation of Korea (NRF) RS-2023-00275456National Research Foundation of Korea (NRF) RS-2024-00463774U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA244726-01
6 · The paper itself

Abstract

Current SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccines have shown robust induction of neutralizing antibodies and CD4

Identifiers

PMID41813804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.