Evidence map›Paper›PMID 41813699›Full record

ArticleNature communications2026

RejuAgro A as an antimicrobial for fire blight control of pome fruits and beyond.

Jian Huang, Ton Nu Bao Vy Huyen, Xiangyang Liu, Shreyashi Mitra, Manda Yu, Quan Zeng, George W Sundin, Kerik D Cox, Helga Förster, James E Adaskaveg and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jian HuangT3 Bioscience, Milwaukee, WI, USA.
Ton Nu Bao Vy HuyenDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.ORCID http://orcid.org/0009-0000-9942-9023
Xiangyang LiuT3 Bioscience, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-6135-668X
Shreyashi MitraDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Manda YuDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-5932-9597
Quan ZengDepartment of Plant Pathology and Ecology, The Connecticut Agricultural Experiment Station, New Haven, CT, USA.
George W SundinDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0003-4078-8368
Kerik D CoxSection of Plant Pathology and Plant-Microbe Biology, School of Integrative Plant Science, Cornell AgriTech, Cornell University, Geneva, NY, USA.
Helga FörsterDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
James E AdaskavegDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Chih-Horng KuoInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0002-2857-0529
Xiaochen YuanDepartment of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, IA, USA.
Russell L CuhelSchool of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Ching-Hong YangDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. chyang@uwm.edu.ORCID http://orcid.org/0000-0001-5330-7055

Funding

United States Department of Agriculture–National Institute of Food and AgricultureUniversity of Wisconsin–Milwaukee Research Foundation
6 · The paper itself

Abstract

Fire blight, caused by Erwinia amylovora, severely impacts global apple and pear production. Current control measures rely heavily on conventional antibiotics like streptomycin, oxytetracycline, and kasugamycin, which raise concerns regarding resistance development and environmental impacts. This research introduces RejuAgro A (RAA), an antimicrobial produced by Pseudomonas soli 0617-T307, showing potent activity against E. amylovora, including streptomycin-resistant strains. RAA demonstrates efficacy comparable to streptomycin in field trials, effectively reducing fire blight incidence. Studies on the antimicrobial mechanism reveal that RAA inhibits RNA, DNA, and protein synthesis, distinguishing from that of conventional antibiotics. Furthermore, RAA displays broad-spectrum activity against diverse plant bacterial and fungal pathogens. The RAA biosynthesis gene cluster in P. soli is identified, revealing key genes essential for its production. RAA presents an alternative to traditional antibiotics, potentially enhancing sustainable apple and pear production and addressing antibiotic resistance concerns.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsErwinia amylovoraFruitMalusPlant DiseasesPseudomonasPyrusMultigene FamilyAnti-Bacterial AgentsAnti-Infective Agents

Identifiers

PMID41813699
PMCPMC12979589

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.