Evidence map›Paper›PMID 41813671›Full record

ArticleNature communications2026

CD8

Jialin Dai, Taijie Jin, Gaixiu Su, Xu Han, Jun Wang, Chenlu Liu, Wenjie Zheng, Qiuye Zhang, Ranran Zhang, Hye Sun Kuehn and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jialin Dai *Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Liangzhu Laboratory of Zhejiang University, Hangzhou, China.
Taijie Jin *Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Liangzhu Laboratory of Zhejiang University, Hangzhou, China.
Gaixiu Su *Department of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Xu Han *Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Liangzhu Laboratory of Zhejiang University, Hangzhou, China.
Jun WangDepartment of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Liangzhu Laboratory of Zhejiang University, Hangzhou, China.
Chenlu LiuLife Sciences Institute, Zhejiang University, Hangzhou, China.
Wenjie ZhengThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qiuye ZhangDepartment of Pediatric Nephrology, Rheumatology and Immunity, The Affiliated Hospital of Qingdao University, Qingdao, China.
Ranran ZhangDepartment of Pediatric Nephrology, Rheumatology and Immunity, The Affiliated Hospital of Qingdao University, Qingdao, China.
Hye Sun KuehnImmunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0002-2154-3966
Jun YangDepartment of Rheumatology and Immunology, Shenzhen Children's hospital, Shenzhen, China.
Li GuoDepartment of Rheumatology Immunology & Allergy, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Dan ZhangDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Ming LiDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Yingjie XuDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Tong YueDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Min WenDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Jia ZhuDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Min KangDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Jianming LaiDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Feifei WuDepartment of Rheumatology and Immunology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Shihao WangLife Sciences Institute, Zhejiang University, Hangzhou, China.
Jiahui ZhangLife Sciences Institute, Zhejiang University, Hangzhou, China.
Ivona AksentijevichInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6564-7214
Sergio D RosenzweigImmunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Pui Y LeeDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5779-4193
Junying YuanInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. junying_yuan@sioc.ac.cn.ORCID http://orcid.org/0000-0003-2405-6036
Xiaomin YuDepartment of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Liangzhu Laboratory of Zhejiang University, Hangzhou, China. yuxiaomin78@gmail.com.ORCID http://orcid.org/0000-0001-6884-3408
Qing ZhouDepartment of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Liangzhu Laboratory of Zhejiang University, Hangzhou, China. zhouqingnwu@gmail.com.ORCID http://orcid.org/0000-0003-0290-1286

Funding

China Postdoctoral Science Foundation 2023M733104National Natural Science Foundation of China (National Science Foundation of China) 32300618National Natural Science Foundation of China (National Science Foundation of China) 82225022, 32141004 and 32321002National Natural Science Foundation of China (National Science Foundation of China) 82394424Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LHDMY23H100005
6 · The paper itself

Abstract

Systemic autoinflammatory diseases (SAID) with inborn errors of cell death (IECD) are caused by overactivation of programmed cell death (PCD). However, the pathogenesis by which PCD leads to autoinflammation remains unclear. Here, we identified IECD patients carrying compound heterozygous RIPK1 variants K377E/R390G with autoinflammatory manifestations. Mechanistically, K377E and R390G mutations suppress NF-κB signaling and activate RIPK1 to promote cell death. CD8

Indexed as

CD8-Positive T-LymphocytesHereditary Autoinflammatory DiseasesReceptor-Interacting Protein Serine-Threonine KinasesAnimalsCell DeathCytokinesFemaleHumansInflammationInterferon-gammaMacrophagesMaleMonocytesMutationNF-kappa BSignal TransductionCytokinesInterferon-gammaNF-kappa BReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID41813671
PMCPMC13181087

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.