Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Mengting Wang *Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Liping Wang *Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Qingqing Cai *Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Yanxin HuangClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Shanru YiClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Heng PanState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.ORCID http://orcid.org/0000-0002-5407-5687
Wenqiang LiuClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-5974-9900
Hong WangClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Hongjie YaoState Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. yao_hongjie@gzlab.ac.cn.ORCID http://orcid.org/0000-0003-2144-0147
Shaorong GaoClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China. gaoshaorong@tongji.edu.cn.ORCID http://orcid.org/0000-0003-1041-3928
Jiayu ChenClinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signal Transduction and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China. chenjiayu@tongji.edu.cn.ORCID http://orcid.org/0000-0003-4755-8901
Funding
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021YFA1100300Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFC2702200Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2024YFA1802300National Natural Science Foundation of China (National Science Foundation of China) 32270856National Natural Science Foundation of China (National Science Foundation of China) 32270858National Natural Science Foundation of China (National Science Foundation of China) 32330030National Natural Science Foundation of China (National Science Foundation of China) 32470908National Natural Science Foundation of China (National Science Foundation of China) 32488101
6 · The paper itself
Abstract
Oocyte development requires tight regulation of transcription and RNA metabolism, which is coordinated by RNA-binding proteins, whose roles in mammalian oogenesis remain incompletely understood. Here, we identify the DEAD-box RNA helicase DDX5 as a key regulator of RNA homeostasis in oocytes. Oocyte-specific deletion of DDX5 leads to female sterility, which is characterized by defective chromatin remodeling, meiotic arrest, increased aneuploidy, and fertilization failure. Mechanistically, DDX5 maintains RNA homeostasis through three interconnected processes: (1) promoting transcription via interaction with RNA polymerase II in nonsurrounded nucleolus-stage germinal vesicle oocytes; (2) clearing retrotransposon RNAs to safeguard transcriptome integrity; and (3) supporting maternal mRNA storage by coordinating nuclear export, mitochondrial organization, and mitochondria-associated ribonucleoprotein domain assembly. Our study establishes DDX5 as a master regulator that integrates transcriptional and post-transcriptional programs to ensure oocyte competence and fertility.
Indexed as
DEAD-box RNA HelicasesOocytesOogenesisRNAAnimalsChromatin Assembly and DisassemblyFemaleGene Expression Regulation, DevelopmentalHomeostasisInfertility, FemaleMeiosisMiceMitochondriaRetroelementsRNA Polymerase IITranscription, GeneticDdx5 protein, mouseDEAD-box RNA HelicasesRetroelementsRNARNA Polymerase II
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
DDX5 orchestrates RNA homeostasis to ensure oocyte developmental competence. · full record | OpenQuestion