ArticlePest management science2026
Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione-resistant Amaranthus tuberculatus biotype.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAmaranthus tuberculatus (waterhemp) is a major agricultural weed known for its rapid evolution of resistance to multiple herbicide modes-of-action. Resistance to 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors such as mesotrione is particularly concerning, yet the underlying genetic and molecular mechanisms remain incompletely understood. This study investigated the basis of mesotrione resistance in a Canadian waterhemp population (biotype 714) using an integrated genomic and transcriptomic approach.
resultsA genome-wide association study (GWAS) on 152 individuals identified 11 unique single nucleotide polymorphisms (SNPs) significantly associated with resistance, with the most significant SNP located on chromosome 13 (P < 10
conclusionMesotrione resistance in this A. tuberculatus population is a complex, polygenic trait. Our findings indicate that resistance is not conferred by a single mechanism, but rather by an enhanced metabolic capacity to mitigate herbicide-induced oxidative stress. This multifaceted defense involves the coordinated regulation of numerous detoxification, signaling, and metabolic pathways. Understanding this complex form of nontarget-site resistance (NTSR) is critical for devising future management strategies to combat the spread of herbicide-resistant weeds. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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