ArticleThe Journal of veterinary medical science2026
Oral malignant melanoma with rhabdoid cell differentiation and myogenic features in a dog.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Malignant melanoma (MM) is difficult to diagnose because of its pleomorphic morphology and diverse protein profile. We describe a case of canine oral MM that exhibited rhabdoid cell differentiation. The tumor contained two cell types: typical MM cells and aggregated rhabdoid cells. Immunohistochemically, both types of neoplastic cells were positive for vimentin and desmin. Typical MM cells are positive for melanocytic markers; a subset of rhabdoid cells is negative for melanocytic markers and positive for myogenin. Consequently, the tumor was diagnosed as an MM with rhabdoid cell differentiation. This case highlights a potential diagnostic pitfall, as the morphological and immunohistochemical features may closely mimic those of collision tumors and myogenic tumors.
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