Evidence map›Paper›PMID 41812662›Full record

ArticleCell2026

Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility.

Jérémie Rispal, Jasmine R Garcia, Brisa Palikuqi, Manasa Vegesna, Dedeepya Vaka, Seung Woo Kang, Coralie Trentesaux, Juan Du, Nicola R Realini, Paige N Spencer and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. mSphere · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jérémie RispalProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
Jasmine R GarciaProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
Brisa PalikuqiProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
Manasa VegesnaDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.
Dedeepya VakaDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.
Seung Woo KangDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN, USA.
Coralie TrentesauxProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
Juan DuDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Nicola R RealiniInstitute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Paige N SpencerDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN, USA.
James M GardnerDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Annika HausmannInstitute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Michael G KattahDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Ken S LauDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN, USA.
Dario BoffelliDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA. Electronic address: ophir.klein@csmc.edu.

Funding

Integrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6M
Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyRC2DK140862 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI SARAH E BLUTT, DARIO BOFFELLI · 2024 to 2026
$6.0M
The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironmentU01DK103147 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2014 to 2023
$5.4M
Training Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4M
Tuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseR01DK103831 · NIDDK · VANDERBILT UNIVERSITY · PI LAU, KEN S · 2016 to 2024
$4.4M
Genetic regulation of epithlial injury in ulcerative colitisR01DK141679 · NIDDK · MAYO CLINIC ROCHESTER · PI KATTAH, MICHAEL GEORGE · 2025 to 2025
$2.8M
Proinflammatory properties of Paneth cells in intestinal inflammationF31DK127687 · NIDDK · VANDERBILT UNIVERSITY · PI SPENCER, PAIGE NICOLE · 2021 to 2023
$104k
NCI NIH HHS T32 CA119925NICHD NIH HHS T32 HD007502NIDDK NIH HHS F31 DK127687NIDDK NIH HHS R01 DK103831NIDDK NIH HHS R01 DK141679NIDDK NIH HHS RC2 DK140862NIDDK NIH HHS U01 DK103147
6 · The paper itself

Abstract

The regionalized structure of the intestinal epithelium is critical for its function, and the risk for certain diseases has a regional bias. However, how regionalization is established and how it influences disease susceptibility remain poorly understood. Here, we investigated the role of the gut microbiome-the regionalized community of microorganisms in the intestinal lumen-in promoting regionalization of the colon. We found that the proximo-distal identity of colonocytes along the organ's length is disrupted in mice lacking a microbiome and that the proximal colonic microbiome produces high levels of nicotinic acid, which induces Pparα expression to establish proximal colonocyte identity. Furthermore, we report that microbiome-driven proximal identity confers protection against tissue injury in the mouse. Finally, we determined that the human colon is regionalized and loses its proximal identity during certain disease states.

Indexed as

ColonGastrointestinal MicrobiomeNiacinAnimalsColitisHumansIntestinal MucosaMaleMiceMice, Inbred C57BLPPAR alphaNiacinPPAR alphacoloncolonocytesdextran sodium sulfateepitheliumhost-microbiome interactionsinflammatory bowel diseasemetabolismmicrobiomenicotinic acidregionalization

Identifiers

PMID41812662
PMCPMC13088955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.