Evidence map›Paper›PMID 41812549›Full record

ArticleHuman immunology2026

Pre-existing influenza antibodies, younger age, and increased CD4 T

Christiane Rollenhagen, Gomathy Parvathinathan, Margaret R Stedman, Geetha Chalasani, Kelly A Birdwell, M Lee Sanders, Mohan Ramkumar, Lauren E Higdon, Naiqing Ye, Jefferson J S Santos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christiane RollenhagenGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA.
Gomathy ParvathinathanDepartment of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA, USA.
Margaret R StedmanDepartment of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA, USA.
Geetha ChalasaniDepartment of Medicine, Pittsburgh VA Medical Center, Pittsburgh, PA, USA.
Kelly A BirdwellDepartment of Medicine, Tennessee VA Medical Center, Nashville, TN, USA.
M Lee SandersDepartment of Medicine, Iowa VA Medical Center, Iowa City, IA, USA.
Mohan RamkumarDepartment of Medicine, Pittsburgh VA Medical Center, Pittsburgh, PA, USA.
Lauren E HigdonGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA; Department of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA, USA.
Naiqing YeDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jefferson J S SantosDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Scott E HensleyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jonathan S MaltzmanGeriatric Research Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA; Department of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA, USA. Electronic address: maltzman@stanford.edu.

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENSLEY, SCOTT · 2021 to 2025
$50.7M
CSRD VA I01 CX001971NIH HHS 75N93021C00015
6 · The paper itself

Abstract

Recipients of kidney transplants require lifelong immunosuppression therapy which is associated with a reduced response to vaccinations. We conducted a longitudinal study of influenza vaccination in US Veteran kidney transplant recipients and correlated demographic factors and T cell characteristics to the immunological outcome of the vaccination. Our data suggest that a consistent history of annual vaccination during the 3 years prior is linked to an increase in influenza antibodies prior to vaccination. High influenza titers post-vaccination are associated with younger age, increased CD4 T

Indexed as

Antibodies, ViralCD4-Positive T-LymphocytesInfluenza, HumanInfluenza VaccinesKidney TransplantationAdultAgedAge FactorsFemaleHumansImmunoglobulin GLongitudinal StudiesMaleMiddle AgedTransplant RecipientsVaccinationAntibodies, ViralImmunoglobulin GInfluenza VaccinesInfluenzaKidney TransplantVaccination

Identifiers

PMID41812549
PMCPMC13227456

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.