Environmental Mixture Toxicity of Guanitoxin and Organophosphates in Zebrafish: from Developmental and Neurobehavioral Phenotypes to Transcriptomic Responses.

Larissa Souza Passos, Melissa von Wyl, Elisabeth M-L Janssen, David Lopez-Rodriguez, Ernani Pinto, Colette Vom Berg

Abstract read

In one paragraph

Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Larissa Souza PassosLaboratory of Environmental Toxicology, Center for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, São Paulo 13416-000, Brazil.

Melissa von WylDepartment of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf 8600, Switzerland.

Elisabeth M-L JanssenDepartment of Environmental Chemistry, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf 8600, Switzerland.ORCID 0000-0002-5475-6730

David Lopez-RodriguezDepartment of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf 8600, Switzerland.

Ernani PintoLaboratory of Environmental Toxicology, Center for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, São Paulo 13416-000, Brazil.ORCID 0000-0001-7614-3014

Colette Vom BergDepartment of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf 8600, Switzerland.ORCID 0000-0002-8870-9799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanitoxin, a neurotoxin produced by cyanobacteria and the only known naturally occurring organophosphate, poses environmental risks comparable to synthetic organophosphate insecticides. Its effects on aquatic organisms, particularly in combination with compounds sharing similar mechanisms of action, remain poorly understood. This study evaluated the developmental toxicity of guanitoxin, alone and combined with the organophosphate insecticides malathion and trichlorfon, in zebrafish (

Indexed as

Cyanobacteria ToxinsOrganophosphatesWater PollutantsAnimalsPhenotypeTranscriptomeZebrafishCyanobacteria ToxinsOrganophosphatesWater Pollutantscardiotoxicitycyanobacteriacyanotoxinsecotoxicologypesticides

Identifiers

PMID41812223

DOI10.1021/acs.est.5c16673

PMCPMC13045019

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.