Evidence map›Paper›PMID 41811965›Full record

ArticleScience advances2026

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer.

Heather Karner, Tabea C Mittmann, Vicky W Chen, Ashir A Borah, Andreas Langen, Hassan Yousefi, Lisa Fish, Balyn W Zaro, Albertas Navickas, Hani Goodarzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Heather KarnerDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6546-2319
Tabea C MittmannDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0009-7567-6252
Vicky W ChenDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0002-9420-4591
Ashir A BorahDepartment of Urology, University of California San Francisco, San Francisco, San Francisco, CA, USA.
Andreas LangenDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA, USA.
Hassan YousefiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5867-1531
Lisa FishDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9184-0512
Balyn W ZaroDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA, USA.ORCID 0000-0002-8938-9889
Albertas NavickasDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0016-2643
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9648-8949

Funding

Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
NCI NIH HHS T32 CA108462
6 · The paper itself

Abstract

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet the extent of contribution from posttranscriptional regulation remains unclear. Here, we systematically measured messenger RNA (mRNA) dynamics across diverse breast cancer models, revealing that mRNA stability substantially shapes gene expression variability. To decipher these dynamics, we developed GreyHound, an interpretable multimodal deep-learning framework integrating RNA sequence features and RNA binding protein (RBP) expression. GreyHound identified an extensive network of RBPs and their regulons underlying variations in mRNA stability, including a regulatory axis centered on RBP RBMS3 and redox regulator TXNIP.

Indexed as

Breast NeoplasmsGene Expression Regulation, NeoplasticRNA, MessengerRNA StabilityAnimalsCell Line, TumorFemaleHumansMiceNeoplasm MetastasisRNA-Binding ProteinsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID41811965
PMCPMC12978252

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.