ArticleJournal of immunology research2026
Immunophenotypic Stratification of Primary Sjögren's Syndrome Reveals Distinct Lymphocyte Profiles and Clinical Manifestations.
Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Immunophenotypic Stratification of Primary Sjögren's Syndrome Reveals Distinct Lymphocyte Profiles and Clinical Manifestations.Journal of immunology research · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectivePrimary Sjögren's syndrome (pSS) is a heterogeneous autoimmune disorder with diverse clinical manifestations and limited effective therapies. This study aimed to stratify pSS patients into distinct immunophenotypic subgroups based on peripheral lymphocyte profiles and to explore the clinical relevance of these subgroups, thereby informing personalized management for pSS.
methodsA retrospective cohort of 133 Chinese pSS patients and 241 age- and sex-matched healthy controls (HCs) was analyzed. Immunophenotyping of 11 lymphocyte subsets was performed using flow cytometry in peripheral blood. K-means clustering was employed to identify patient subgroups based on lymphocyte profile. Clinical data were collected and compared across clusters.
resultsLymphocyte profiles in pSS patients differed from those in HCs, featuring elevated proportions and estimated counts of activated CD8
conclusionLymphocyte profiling may help stratify pSS patients into clinically distinct subgroups, potentially corresponding to different pathobiological endotypes, and could thus inform patient stratification.
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