Evidence map›Paper›PMID 41811906›Full record

ReviewJournal of immunology research2026

Proportion, Function, and Generation of Dual Receptor Lymphocytes.

Qi Peng, Lanwei Zhu, XiaoPing Lu, Xinsheng Yao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qi PengDepartment of Immunology, Center of Immunomolecular Engineering, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China, zmc.edu.cn.
Lanwei ZhuDepartment of Immunology, Center of Immunomolecular Engineering, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China, zmc.edu.cn.
XiaoPing LuDepartment of Immunology, Center of Immunomolecular Engineering, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China, zmc.edu.cn.
Xinsheng YaoDepartment of Immunology, Center of Immunomolecular Engineering, Innovation and Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China, zmc.edu.cn.ORCID https://orcid.org/0000-0001-6960-4003

Funding

Guizhou Provincial High-level Innovative Talents Project (2018) 5637National Natural Science Foundation of China 82471630
6 · The paper itself

Abstract

The specific immune response mechanisms of B cells and T cells are centered on the classic clonal selection theory, which posits that "a single lymphocyte expresses only one type of antigen receptor." This mechanism is primarily achieved through V(D)J allelic exclusion rearrangement on germline chromosomes and rigorous self-tolerance selection. However, accumulating experimental evidence indicates that phenomena such as incomplete allelic exclusion rearrangement (i.e., allelic inclusion rearrangement), escape from central tolerance selection, and peripheral immune receptor editing can induce the generation of dual-receptor lymphocytes, including "dual-BCR B cells," "dual-TCR T cells," and "TCR

Indexed as

B-LymphocytesLymphocytesReceptors, Antigen, B-CellReceptors, Antigen, T-CellT-LymphocytesAnimalsHumansMiceV(D)J RecombinationReceptors, Antigen, B-CellReceptors, Antigen, T-Celldual-BCR B cellsdual-receptor lymphocytesdual-TCR T cellsreceptor editingsingle-cell RNA+VDJ sequencing technologyTCR+BCR+ lymphocytesV(D)J allelic exclusion rearrangementV(D)J allelic inclusion rearrangement

Identifiers

PMID41811906
PMCPMC13140939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.