Evidence map›Paper›PMID 41811903›Full record

ReviewJournal of immunology research2026

CAR-Cell Therapy for Autoimmune Diseases: From the Laboratory to Clinical Practice.

Xiao-Peng Zhang, Yi-Dong Chen, Qi Yu, Fang Liu, Jia-Min Li, Shuang Li, Yi-Yu Cheng, Xiao-Yu Fu, Qian-Xi Xia, Jun-Rong Li and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiao-Peng ZhangDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0007-3200-4347
Yi-Dong ChenDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0000-0002-7866-7628
Qi YuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0008-9726-0189
Fang LiuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0008-0151-8748
Jia-Min LiDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0007-7963-4880
Shuang LiDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0009-9791-8849
Yi-Yu ChengDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0000-0003-1423-162X
Xiao-Yu FuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0000-6497-2456
Qian-Xi XiaDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0009-0004-1205-5049
Jun-Rong LiDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0000-0002-8292-990X
Xiao-Hua HouDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0000-0002-3694-2126
Liang-Ru ZhuDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, tjmu.edu.cn.ORCID https://orcid.org/0000-0002-7372-294X

Funding

National Key Research and Development Program of China 2018YFC0114600National Key Research and Development Program of China 2023YFC2507300National Natural Science Foundation of China 81873558National Natural Science Foundation of China 82170547
6 · The paper itself

Abstract

Autoimmune diseases (AIDs) are characterized by a breakdown in immune tolerance, wherein the patient's immune system fails to recognize self-tissues and subsequently attacks the body's organs and tissues. Although there are many therapeutic medicines targeting the pathogenic mechanisms, there is currently a lack of curative or long-term symptom control options. Chimeric antigen receptor (CAR) cells are engineered cells that express multifunctional synthetic receptors. These CAR cells specifically target killer pathogenic immune cells and offer a novel approach to treating AIDs by modulating the immune microenvironment. Recent studies have demonstrated satisfactory outcomes with this method in managing autoimmune conditions. In our review paper, we provide a comprehensive summary of previous cases utilizing CAR cell therapy for AIDs. We hope that our review will provide clinicians with more options for the treatment of AIDs.

Indexed as

Autoimmune DiseasesImmunotherapy, AdoptiveReceptors, Chimeric AntigenAnimalsHumansReceptors, Chimeric Antigenautoimmune diseasescellular immunotherapychimeric antigen receptor cells

Identifiers

PMID41811903
PMCPMC13140878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.