Evidence map›Paper›PMID 41811839›Full record

ArticleJournal of immunology research2026

The Abnormal Expression of B7-H4 Is Associated With the Pathogenesis of Autoimmune Thyroid Diseases.

Yuqing Wu, Jianbin Xu, TianTian Cai, Yudie Fang, Zhaowei Huang, Xinwei Zhang, Guangxin Li, Wenyu Xu, Jinan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqing WuGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0008-5921-0500
Jianbin XuDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.
TianTian CaiDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.ORCID https://orcid.org/0000-0001-9475-1654
Yudie FangDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.
Zhaowei HuangDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.ORCID https://orcid.org/0000-0002-4086-0465
Xinwei ZhangDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.
Guangxin LiDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.
Wenyu XuDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.ORCID https://orcid.org/0000-0002-2408-3061
Jinan ZhangDepartment of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.ORCID https://orcid.org/0000-0002-1700-4695

Funding

Clinical Research Center of Thyroid Diseases of Shanghai Health Medical College 20MC20200002National Natural Science Foundation of China 82370791Shanghai Pudong New Area Health Commission PWZxk2022-22Shanghai Pudong New Area Science and Technology development Fund Public Institutions Livelihood Research Project PKJ2023A-Y10
6 · The paper itself

Abstract

backgroundB7-H4 is an immunosuppressive molecule extensively studied in tumor diseases and is also of interest in some autoimmune diseases. However, the relationship between B7-H4 and autoimmune thyroid diseases (AITDs) has not been explored.

objectiveTo investigate the B7-H4 expression in different tissues of patients with different subtypes of AITDs.

methodsThe B7-H4 protein expression in thyroid tissue of the participants was identified through immunohistochemical analyses while concentrations of plasma soluble B7-H4 (sB7-H4) were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, B7-H4 mRNA expression in peripheral blood mononuclear cells (PBMCs) was evaluated via RT-PCR.

resultsThe immunohistochemical findings revealed a decrease in levels of B7-H4 protein in thyroid tissue of Graves' disease (GD) and Hashimoto's thyroiditis (HT) patients, compared with those of the normal controls. Similarly, a decrease was observed in the level of B7-H4mRNA expression in PBMCs assayed via RT-PCR. However, based on ELISA results, plasma levels of sB7-H4 were increased in both GD and HT patients compared to those in normal controls.

conclusionThe abnormal expression of B7-H4 in AITD patients suggests that it may be involved in the onset and progression of the disease. At the same time, the mechanism of action of B7-H4 in AITD and whether it is a potential therapeutic target need to be further studied.

Indexed as

Graves DiseaseHashimoto DiseaseThyroid GlandV-Set Domain-Containing T-Cell Activation Inhibitor 1AdultBiomarkersFemaleHumansImmunohistochemistryLeukocytes, MononuclearMaleMiddle AgedRNA, MessengerThyroiditis, AutoimmuneBiomarkersRNA, MessengerV-Set Domain-Containing T-Cell Activation Inhibitor 1VTCN1 protein, humanabnormalityautoimmune thyroid diseaseB7-H4expression

Identifiers

PMID41811839
PMCPMC13140884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.