Evidence map›Paper›PMID 41811810›Full record

ReviewJournal of immunology research2026

The Role of Neuro-Immune Regulation in the Pathogenesis of Psoriasis.

Xin Liu, Mingyu Yu, Pan Zou, Suwen Liu, Jian Jiang, Liyang Ge, Su Jiang, Jingyu Zhang, Xin Wang, Hongxiang Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin LiuDepartment of Dermatology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei, China, znhospital.cn.
Mingyu YuDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.ORCID https://orcid.org/0009-0006-3750-6162
Pan ZouDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.ORCID https://orcid.org/0000-0002-1712-1680
Suwen LiuDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Jian JiangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Liyang GeDepartment of Dermatology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei, China, znhospital.cn.
Su JiangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Jingyu ZhangDepartment of Dermatology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei, China, znhospital.cn.ORCID https://orcid.org/0000-0002-5138-5372
Xin WangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Hongxiang ChenDepartment of Dermatology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei, China, znhospital.cn.ORCID https://orcid.org/0000-0003-0989-3565

Funding

National Natural Science Foundation of China 82573979
6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic inflammation. Sensory neurons not only perceive various external stimuli but also participate in skin immune regulation and barrier repair through the release of neuropeptides and neurotransmitters. This review systematically compiles current research advancements concerning the altered neural innervation patterns in psoriatic lesions, the pathophysiological functions of sensory neuron-specific receptors and ion channels, and the regulatory mechanisms of neuropeptides in disease pathogenesis. By elucidating the precise contributions of sensory neurons to the development of psoriasis, this work seeks to further clarify their specific role in the disease and provide new insights for enhancing the understanding of its pathogenesis, thereby informing the development of more targeted therapeutic strategies.

Indexed as

NeuroimmunomodulationPsoriasisSensory Receptor CellsSkinAnimalsHumansKeratinocytesNeuropeptidesNeuropeptidesimmunityinflammatory responseneuropeptidespsoriasissensory neurons

Identifiers

PMID41811810
PMCPMC13140319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.