ArticleMolecular biology of the cell2026
A minimal model for the role of Rim4 in regulating meiotic exit in budding yeast.
Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Meiosis ensures the formation of haploid gametes through two rounds of chromosome segregation after one round of DNA replication. How this cell-cycle process is restricted to two, and only two divisions, is poorly understood. In budding yeast, RNA-binding protein Rim4 binds various mRNAs to prevent their translation. At the onset of meiosis II, phosphorylation and degradation of Rim4, along with the concomitant release of sequestered mRNA, play an important role in ensuring meiotic exit. Building on previous work, we developed a parsimonious mathematical model of meiotic termination that elucidates the role of Rim4-mRNA release and translation of
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