ArticlePhysiological research2026
Protective Effects of Opuntiol on Lipopolysaccharide-Induced Acute Kidney Injury in Mice.
Article in Physiological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the protective effect of opuntiol, a naturally occurring flavonoid, against lipopolysaccharide (LPS)-induced acute kidney injury in mice. Acute kidney injury (AKI) is a serious clinical complication characterized by inflammation, oxidative stress, and apoptosis, often resulting in high morbidity and mortality. Male mice were divided into six groups and administered opuntiol (25, 50 and 100 mg/kg b. wt.) intraperitoneally prior to LPS (10 mg/kg b. wt.) administration. The most effective dose was 50 mg/kg b. wt., as indicated in the dose-finding study. Kidney function markers (urea, creatinine, blood urea nitrogen (BUN), uric acid), antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), cyclooxygenase-2 (COX-2), and gene expression levels (pro-inflammatory, apoptotic, and antioxidant genes) were analyzed using biochemical assays and qRT-PCR. Opuntiol significantly reduced elevated levels of serum urea, creatinine, BUN, and uric acid compared to the LPS group. Further, opuntiol restored antioxidant enzyme activities and MDA levels were significantly decreased. Opuntiol also downregulated inflammatory markers and gene expressions (TNF-alpha, NF-kappaB, TLR4, Bax, Caspase-3, etc.) while upregulating anti-apoptotic (Bcl-2) and antioxidant (Nrf-2) genes. Opuntiol offers significant protection against LPS-induced AKI by mitigating oxidative damage, inflammation, and apoptotic signaling. It enhances renal function and promotes antioxidant defense. These findings support the therapeutic potential of opuntiol as a novel nephroprotective agent in managing sepsis-associated kidney injury and encourage further preclinical and clinical investigations. Key words Opuntiol " Acute kidney injury " Lipopolysaccharide " Oxidative stress " Inflammation " Apoptosis.
Indexed as
Identifiers
41811703PMC13128012What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.