Evidence map›Paper›PMID 41811667›Full record

ArticleNeuroscience bulletin2026

Astrocyte-Specific Upregulation of Tumor Necrosis Factor Receptor II Ameliorates Pathological Phenotypes in APP

Dafeng Li, Yang Li, Lang Wen, Zuolong Chen, Feng Gao, Yong Shen, Qiong Wang

Abstract read
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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dafeng LiDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China.
Yang LiDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China.
Lang WenDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China.
Zuolong ChenDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China.
Feng GaoDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China.
Yong ShenDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China. yongshen@ustc.edu.cn.ORCID http://orcid.org/0000-0002-5048-8134
Qiong WangDepartment of Neurology, I'nstitute on Aging and Brain Disorders, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230026, China. qiongw@ustc.edu.cn.ORCID http://orcid.org/0000-0002-1043-7826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our earlier research showed that deletion of tumor necrosis factor-α receptor II (TNFRII) exacerbated Alzheimer's disease (AD) associated pathology in the AD mouse model. Previous studies have demonstrated that TNFRII was mainly expressed in astrocytes. However, whether AD-associated pathology can be modified by targeting TNFRII in astrocytes remains unknown. Here, we showed that TNFRII was decreased in astrocytes in AD brains. Then, we developed transgenic mouse models (astrocyte-specific expression of human TNFRII mice, TNFRII

Indexed as

Alzheimer’s diseaseAPPNL-F/NL-F miceAstrocytesTNFRII

Identifiers

PMID41811667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.