Evidence map›Paper›PMID 41811595›Full record

Observational studyEndocrine2026

Characteristics and etiological profile of bilateral adrenal nodules: A Post-hoc analysis.

Jiayu Li, Yuan Xiong, Junlong Li, Linqiang Ma, Ying Song, Rong Luo, Zhixiao Luo, Yun Mao, Hang Shen, Jinbo Hu and 4 more

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04682938 (The Prevalence and Characteristics of Adrenal Incidentaloma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04682938 completednot on this map

The Prevalence and Characteristics of Adrenal Incidentaloma: A Prospective Study

TypeobservationalSponsorChongqing Medical UniversityRan2020 to 2021Enrolled25,356ConditionsPrevalence, Adrenal Incidentaloma
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiayu Li *Department of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuan Xiong *Department of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Junlong LiDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Linqiang MaDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ying SongDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Rong LuoMedical Examination Centre, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhixiao LuoMedical Examination Centre, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yun MaoDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hang ShenDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jinbo HuDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shumin YangDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qifu LiDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. liqifu@yeah.net.
Ying JingDepartment of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 1074334870@qq.com.ORCID 0009-0007-5023-7363
Chongqing Primary Aldosteronism Study (CONPASS) Group

Funding

Chongqing Municipal Science and Technology Bureau 2022ZDXM003Chongqing Technology Innovation and Application Development Special Key Project CSTB2024TIAD-KPX0039National Natural Science Foundation of China 82500961National Natural Science Foundation of China U21A20355
6 · The paper itself

Abstract

objectiveTo investigate the clinical characteristics and etiological profile of bilateral adrenal nodules in an unselected screening population.

methodsThis post-hoc analysis was derived from a cross-sectional study conducted in China in 2021 (ClinicalTrials.gov Identifier: NCT04682938). A total of 25,356 individuals who underwent routine abdominal computed tomography (CT) scans at the Health Management Center of the First Affiliated Hospital of Chongqing Medical University between November 2020 and November 2021 were enrolled. Patients with adrenal nodules detected on CT were further evaluated for nodule malignancy and hormonal function.

resultsAmong the 25,356 participants who underwent abdominal CT, adrenal nodules were detected in 351 individuals, with bilateral lesions accounting for 9.1% (32/351). Participants with bilateral and unilateral nodules showed no significant differences in baseline characteristics. Of the 25 participants with bilateral nodules who completed endocrine testing, nonfunctioning adenomas (NFA) accounted for 48% (n = 12), functioning lesions including cortisol autonomy and primary aldosteronism (PA) accounted for 40% (n = 10), and infectious lesions (tuberculosis) comprised the remaining 12% (n = 3). Tuberculosis was significantly more prevalent in bilateral nodules than in unilateral nodules (p = 0.004), while the prevalence of functioning lesions was similar between the two groups (p = 0.464 for cortisol autonomy; p = 0.168 for PA).

conclusionBilateral adrenal nodules account for 9.1% of all patients with adrenal nodules in the general population. Bilateral adrenal nodules share etiological similarities with unilateral nodules but exhibit a higher proportion of infectious lesions.

Indexed as

Adrenal Gland NeoplasmsAdultAgedChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedTomography, X-Ray ComputedAdrenal incidentalomasBilateral adrenal nodulesEtiological distributionPost-hoc analysis

Identifiers

PMID41811595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.