L-arginine functionalized NiFe₂O₄ nanoparticles: synthesis, characterization, antimicrobial activity, and biocompatibility evaluation in a zebrafish model.

Mahaboob Pasha, Deeplata Sharma, Dimpal Prafulchandra Khambhati, Laxmidhar Maharana, Indumathi Thangavelu, Srinivas Tadepalli, Ahmed A Bhran

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Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Mahaboob PashaDepartment of Physics, Presidency University, Bengaluru, Karnataka, India.

Deeplata SharmaDepartment of FBAS (Chemistry), Vivekananda Global University, Jaipur, India.

Dimpal Prafulchandra KhambhatiDepartment of Biomedical Engineering, Faculty of Engineering and Technology, Parul Institute of Technology, Parul University, Vadodara, Gujarat, India.

Laxmidhar MaharanaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

Indumathi ThangaveluDepartment of Chemistry, CHRIST (Deemed to be University), Bangalore, Karnataka, 560029, India.

Srinivas TadepalliDepartment of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Kingdom of Saudi Arabia. stadepalli@imamu.edu.sa.

Ahmed A BhranDepartment of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Kingdom of Saudi Arabia.

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6 · The paper itself

Abstract

NiFe₂O₄ nanoparticles and L-arginine–functionalized NiFe₂O₄ (NiFe₂O4–LA) were synthesized, characterized, and evaluated for antimicrobial performance and in vivo biocompatibility in a zebrafish embryo model. The XRD and HRTEM studies confirmed the formation of single-phase cubic spinel NiFe₂O₄ with average crystallite size ≈ 20–30 nm. Surface modification with LA preserved the spinel structure while reducing crystallinity and hydrodynamic size 128.7 nm. FTIR and XPS verified successful surface functionalization. UV vis measurements showed band-gap narrowing after La conjugation (Eg ≈ 3.23 → 3.15 eV). NiFe₂O₄–LA exhibited enhanced antimicrobial activity compared with bare NiFe₂O₄ against MRSA and C. albicans an effect attributed to enhanced surface interaction and ROS-mediated oxidative damage. The MIC values of C. albicans is found to 1200 µg/mL while in the case MRSA is about 900 µg/mL. The ROS assays with histidine modulation supported a role for redox activity in antimicrobial action. In vivo zebrafish embryo assays showed minimal developmental toxicity at tested exposures with better viability for the LA coated material.

Indexed as

Anti-Infective AgentsArginineBiocompatible MaterialsNanoparticlesAnimalsCandida albicansEmbryo, NonmammalianMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsReactive Oxygen SpeciesZebrafishAnti-Infective AgentsArginineBiocompatible MaterialsReactive Oxygen SpeciesAntimicrobial activityBiocompatibilityLA functionalizationNano biomaterialsNiFe₂O₄ nanoparticlesROSSpinel ferriteZebrafish embryo model

Identifiers

PMID41811582

DOI10.3389/fchem.2021.651053

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