Evidence map›Paper›PMID 41811556›Full record

ArticleThe European physical journal. E, Soft matter2026

Endophytic fungi of Aegle marmelos as a source of novel antibacterials and anti-SARS-CoV agents.

Soniya Goyal, Poonam Bansal, Pardeep Kumar, Dinesh Kumar, Gunjan Sharma, Ashish Sharma, Bhupesh Gupta, Mahiti Gupta, Raman Kumar, Ahmad Umar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European physical journal. E, Soft matter, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Soniya Goyal *Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India.
Poonam Bansal *Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India.
Pardeep KumarDepartment of Mechanical Engineering, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India.
Dinesh KumarDepartment of Mechanical Engineering, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India.
Gunjan SharmaDepartment of Biotechnology, Gujarat Biotechnology University, GIFT City, Gandhinagar, 382355, Gujarat, India.
Ashish SharmaDepartment of Botany and Environment Studies, DAV University, Jalandhar, 144012, Punjab, India.
Bhupesh GuptaDepartment of Computer Science and Engineering, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India.
Mahiti GuptaDepartment of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India. mahitigupta@gmail.com.
Raman KumarDepartment of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to Be University), 133207, Mullana, Haryana, India.
Ahmad UmarDepartment of Chemistry, Faculty of Science and Arts, and Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, Najran-11001, Kingdom of Saudi Arabia.
Tubia AlmasDepartment of Chemistry, Faculty of Science and Arts, and Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, Najran-11001, Kingdom of Saudi Arabia.
Sotirios BaskoutasDepartment of Materials Science, University of Patras, 26504, Patras, Greece. bask@upatras.gr.ORCID 0000-0003-2782-3501

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug resistance in microorganisms is a growing global threat, highlighting the urgent need for novel therapeutic agents. This study evaluates the antibacterial and anti-SARS-CoV potential of fungal endophytes isolated from A. marmelos. Among 16 endophytes screened, the ethyl acetate extract of the #3 AMLBF strain (Fusarium vanettenii) exhibited the strongest antibacterial activity against several pathogens. This extract showed minimum inhibitory concentrations (MICs) ranging from 0.49 to 0.8 µg/ml. GC/MS analysis of the active extract identified 45 compounds. Furthermore, molecular docking against the SARS-CoV-2 spike glycoprotein revealed nine potential ligands, with Anthraergosta-5,7,9,22-tetren-3-ol p-chlorobenzoate showing the most potent binding affinity (- 10.2 kcal/mol), a value exceeding that of the standard chloroquine (- 6.5 kcal/mol). These results indicate that the organic extract from this fungal strain is a promising candidate for the discovery of new antimicrobial agents.

Indexed as

AegleAnti-Bacterial AgentsAntiviral AgentsEndophytesFungiSARS-CoV-2Microbial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsAntiviral Agents

Identifiers

PMID41811556
PMCPMC12979345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.