Evidence map›Paper›PMID 41811533›Full record

ReviewJournal of mammary gland biology and neoplasia2026

Branching out: the diverse roles of stem and progenitor cells in mammary gland development.

Andrew Olander, Shaheen S Sikandar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of mammary gland biology and neoplasia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew OlanderDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, USA.
Shaheen S SikandarDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, USA. ssikanda@ucsc.edu.

Funding

Molecular mechanisms regulating LMO2+ metastasis initiating cellsR37CA269754 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Shaheen Sikandar · 2023 to 2026
$1.4M
Determining the effects of pregnancy and aging on the mammary glandF31CA294932 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Andrew Olander · 2025 to 2026
$86k
NCI NIH HHS F31 CA294932NIH/NCI 1F31CA294932-01A1NIH/NCI R37CA269754NIH/NIGMS 5T32GM133391-04
6 · The paper itself

Abstract

Tissue specific stem cells are critical in maintaining organ function throughout life. Understanding the dynamics and heterogeneity of stem cells and progenitors is essential to understanding how diseased cell states such as cancer evolve. Studies in the mammary gland have revealed significant heterogeneity in stem cell identity during embryonic development, puberty, adulthood and aging. In this review, we discuss the dynamics of lineage commitment in the mammary gland and the current understanding of mammary stem cells versus lineage committed progenitors at different stages. As breast cancer risk increases with age, we also review recent studies on the aged mammary gland in relation to lineage identity and provide perspectives for future research in understanding the niche of mammary epithelial cells.

Indexed as

Mammary Glands, AnimalMammary Glands, HumanStem CellsAnimalsCell DifferentiationCell LineageEpithelial CellsFemaleHumansDifferentiationHeterogeneityLineage commitmentMammary stem cellsProgenitors

Identifiers

PMID41811533
PMCPMC13086781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.