Evidence map›Paper›PMID 41811444›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.

Jill T Kuwabara, Vera Beilinson, Alexis C Hargadon, Grischa Y Chen, Xiao-Meng Hu, Mark S Ladinsky, Kathleen T Hackett, Joseph P Dillard, Karen L Visick, Edward G Ruby and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jill T KuwabaraPacific Biosciences Research Center, Kewalo Marine Laboratory, University of Hawaii at Manoa, Honolulu, HI 96813.
Vera BeilinsonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Alexis C HargadonDivision of Biosphere Sciences and Engineering, Carnegie Science, Pasadena, CA 91125.
Grischa Y ChenDivision of Biosphere Sciences and Engineering, Carnegie Science, Pasadena, CA 91125.
Xiao-Meng HuDivision of Biosphere Sciences and Engineering, Carnegie Science, Pasadena, CA 91125.
Mark S LadinskyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Kathleen T HackettDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI 53705.ORCID 0009-0004-8728-0849
Joseph P DillardDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI 53705.ORCID 0000-0003-1711-7670
Karen L VisickDepartment of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL 60153.ORCID 0000-0002-2400-2591
Edward G RubyPacific Biosciences Research Center, Kewalo Marine Laboratory, University of Hawaii at Manoa, Honolulu, HI 96813.ORCID 0000-0002-4112-4830
Margaret McFall-NgaiPacific Biosciences Research Center, Kewalo Marine Laboratory, University of Hawaii at Manoa, Honolulu, HI 96813.ORCID 0000-0002-6046-6238

Funding

Vibrio fischeri as a Model for Bacterial ColonizationR37AI050661 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI MARGARET J MC FALL-NGAI, Edward G Ruby · 2018 to 2026
$5.4M
Host-associated biofilm formation and dispersal mechanismsR35GM130355 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI Karen L Visick · 2019 to 2026
$3.5M
Vibrio colonization determinants in symbiosisR01GM135254 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2020 to 2023
$1.9M
NIAID NIH HHS R37 AI050661NIGMS NIH HHS R01 GM135254NIGMS NIH HHS R35 GM130355
6 · The paper itself

Abstract

Bacterial outer membrane vesicles (OMVs) and the cargo they carry are increasingly recognized as a means of communication between microbial symbionts and the cells of their host. However, few studies have focused on the biochemical and molecular mechanisms underlying OMV signaling during symbiosis onset and development. We show here that SypC, an OMV protein of the bioluminescent symbiont

Indexed as

Aliivibrio fischeriBacterial Outer Membrane ProteinsDecapodiformesSymbiosisAnimalsBiofilmsBacterial Outer Membrane ProteinsEuprymna scolopesOMVssymbiosistranscriptomicsVibrio fischeri

Identifiers

PMID41811444
PMCPMC12994190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.