Trial reportIndian pediatrics2026
Comparison of Efficacy of Albendazole, Mebendazole and Pyrantel Pamoate in Achieving Remission and Preventing Recurrence of Enterobius vermicularis Infestation in Children: A Randomised Controlled Trial.
Trial report in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Methodological Concerns in the Randomized Trial Comparing Antihelminthics for Enterobiasis.Indian pediatrics · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEnterobius vermicularis also known as pinworm is one of the most common parasitic infestations in humans. Repeated cycles of reinfection make it difficult to eradicate. Therefore, this study was planned to determine the efficacy of drugs in achieving remission and preventing recurrences of pinworm infestation.
methodsThis was an open-label randomized controlled trial conducted from March to August 2025 at Karaikal, Puducherry. Children aged 2-12 years (n = 126) with confirmed pinworm infestation were randomized to one of the three groups (1:1:1)- albendazole (400 mg stat dose), mebendazole (100 mg stat dose) or pyrantel pamoate (11 mg/kg stat dose) with a repeat dose of same drug after two weeks. The efficacy of the three drugs was compared by using a novel objective symptomatic remission (clearance of worms after treatment initiation) and recurrence (no reappearance of worms after remission) scores. Each parent was explained the hygiene measures to be followed and compliance to hygiene was checked in a diary during subsequent visits.
resultsAlbendazole, Mebendazole and Pyrantel pamoate achieved the highest remission score in 70.5%,59.5% and 67.5% respectively; (P value = 0.483). The highest recurrence score was achieved by Mebendazole in 97.6%, followed by pyrantel pamoate (82.1%) and albendazole (69%); (P value = 0.010). The majority of the children (n = 113) practiced proper hygiene, among whom,102 (90.3%) had no recurrence of worms; P value = 0.001.
conclusionAlbendazole, mebendazole and pyrantel pamoate had similar efficacy in inducing remission, while mebendazole was better than the other two agents in preventing recurrences.
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